en
Scientific article
English

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

Published inBrain, vol. 139, no. Pt 1, p. 39-46
Publication date2016
Abstract

See Friese (doi:10.1093/brain/awv349) for a scientific commentary on this article.Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight patients with long-standing relapsing-remitting or secondary progressive multiple sclerosis and eight control patients without neurological disease. Analysis of several hundred individual neurons located in the insular, frontotemporal and occipital lobe revealed a widespread and pronounced loss of dendritic spines in multiple sclerosis cortex that occurs independent of cortical demyelination and axon loss. The presence of a primary synaptic pathology in the normal-appearing cortex of multiple sclerosis patients challenges current disease concepts and has important implications for our understanding of disease progression.

Funding
Citation (ISO format)
JÜRGENS, Tanja et al. Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. In: Brain, 2016, vol. 139, n° Pt 1, p. 39–46. doi: 10.1093/brain/awv353
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0006-8950
571views
6downloads

Technical informations

Creation01/11/2016 6:55:00 PM
First validation01/11/2016 6:55:00 PM
Update time03/15/2023 12:02:17 AM
Status update03/15/2023 12:02:16 AM
Last indexation01/16/2024 7:58:05 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack