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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

Jürgens, Tanja
Jafari, Mehrnoosh
Bahn, Erik
Brück, Wolfgang
Kerschensteiner, Martin
Published in Brain. 2016, vol. 139, no. Pt 1, p. 39-46
Abstract See Friese (doi:10.1093/brain/awv349) for a scientific commentary on this article.Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight patients with long-standing relapsing-remitting or secondary progressive multiple sclerosis and eight control patients without neurological disease. Analysis of several hundred individual neurons located in the insular, frontotemporal and occipital lobe revealed a widespread and pronounced loss of dendritic spines in multiple sclerosis cortex that occurs independent of cortical demyelination and axon loss. The presence of a primary synaptic pathology in the normal-appearing cortex of multiple sclerosis patients challenges current disease concepts and has important implications for our understanding of disease progression.
PMID: 26667278
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Research group La Sclérose en plaques (908)
Projects FNS: PP00P3_152928
Tschira Foundation, Gebert Rüf Foundation, Gemeinnützige Hertiestiftung
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JÜRGENS, Tanja et al. Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. In: Brain, 2016, vol. 139, n° Pt 1, p. 39-46. https://archive-ouverte.unige.ch/unige:79115

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Deposited on : 2016-01-12

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