Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

Brachet, Anne; Mateus, Luis Joël; Cherkaoui, Samir; Christen, Philippe; Gauvrit, J.-Y.; Lantéri, P.; Veuthey, Jean-Luc

doi:10.1051/analusis:1999143

Scientific article

English

Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

Contributors

Brachet, Anne; Mateus, Luis Joël; Cherkaoui, Samir; Christen, Philippe; Gauvrit, J.-Y.; Lantéri, P.; Veuthey, Jean-Luc

Published in

Analusis, vol. 27, no. 9, p. 772-778

Publication date

1999

Abstract

Central composite designs were used in the study of supercritical fluid extraction (SFE) of three tropane alkaloids : hyoscyamine and scopolamine from Datura candida x D. aurea hairy roots and cocaine from coca leaves (Erythroxylum coca). Several SFE parameters, such as pressure, temperature, the nature and percentage of the polar modifier were examined. The tropane alkaloid extraction yield was established as response. A comparison between the predicted and the experimental extraction yields was established in order to assess the prediction quality of the model. Response surfaces were drawn from the mathematical models and enabled to determine the optimal conditions and to visualise the method robustness. The behaviour of the compounds investigated was discussed in relation with the selected SFE parameters.

Keywords

Supercritical fluid extraction
Experimental design
Hyoscyamine
Scopolamine
Cocaine
Plant extract

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

BRACHET, Anne et al. Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts. In: Analusis, 1999, vol. 27, n° 9, p. 772–778. doi: 10.1051/analusis:1999143

Article (Published version)

Identifiers

PID : unige:79073
DOI : 10.1051/analusis:1999143

Additional URL for this publication

http://www.edpsciences.org/10.1051/analusis:1999143

Journal ISSN

0365-4877

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06/01/2016 11:39:00

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06/01/2016 11:39:00

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15/03/2023 00:02:00

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15/03/2023 00:02:00

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31/10/2024 02:26:19

Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation