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Bipolar disorder: Functional neuroimaging markers in relatives

Piguet, Camille
Fodoulian, Léon
Houenou, Josselin
Published in Neuroscience and Biobehavioral Reviews. 2015, vol. 57, p. 284-296
Abstract Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling alterations linked to the liability to BD from those associated with the evolution, medication and comorbidities of BD. Explorations in high risk subjects allow the study of these risk markers. We reported and summarized all functional magnetic resonance imaging (fMRI) studies focusing on first-degree relatives of BD patients. We found 29 studies reporting neural correlates of working memory (WM), emotional processing, executive functions and resting state in relatives of BD patients, compared to healthy subjects. Overall, the same regions that have been involved in patients, such as the inferior frontal gyrus and limbic areas, seem to be functionally altered in high-risk subjects. We conclude that the same brain regions already implicated in the pathophysiology of the disease such as the amygdala are also associated with the risk of BD. However longitudinal studies are required to understand their implication in the transition to BD.
PMID: 26321590
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Article (Published version) (991 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Affective sciences
Thérapeutiques des Troubles de l'Humeur et Anxieux (689)
Mécanismes cérébraux du comportement et des fonctions cognitives (701)
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PIGUET, Camille et al. Bipolar disorder: Functional neuroimaging markers in relatives. In: Neuroscience and Biobehavioral Reviews, 2015, vol. 57, p. 284-296. doi: 10.1016/j.neubiorev.2015.08.015 https://archive-ouverte.unige.ch/unige:78765

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Deposited on : 2015-12-17

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