Bipolar disorder: Functional neuroimaging markers in relatives

Piguet, Camille Marie; Fodoulian, Léon; Aubry, Jean-Michel; Vuilleumier, Patrik; Houenou, Josselin

doi:10.1016/j.neubiorev.2015.08.015

Scientific article

English

Bipolar disorder: Functional neuroimaging markers in relatives

Contributors

Piguet, Camille Marie

; Fodoulian, Léon

; Aubry, Jean-Michel; Vuilleumier, Patrik

; Houenou, Josselin

Published in

Neuroscience and biobehavioral reviews, vol. 57, p. 284-296

Publication date

2015

Abstract

Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling alterations linked to the liability to BD from those associated with the evolution, medication and comorbidities of BD. Explorations in high risk subjects allow the study of these risk markers. We reported and summarized all functional magnetic resonance imaging (fMRI) studies focusing on first-degree relatives of BD patients. We found 29 studies reporting neural correlates of working memory (WM), emotional processing, executive functions and resting state in relatives of BD patients, compared to healthy subjects. Overall, the same regions that have been involved in patients, such as the inferior frontal gyrus and limbic areas, seem to be functionally altered in high-risk subjects. We conclude that the same brain regions already implicated in the pathophysiology of the disease such as the amygdala are also associated with the risk of BD. However longitudinal studies are required to understand their implication in the transition to BD.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

PIGUET, Camille Marie et al. Bipolar disorder: Functional neuroimaging markers in relatives. In: Neuroscience and biobehavioral reviews, 2015, vol. 57, p. 284–296. doi: 10.1016/j.neubiorev.2015.08.015

Article (Published version)

Identifiers

PID : unige:78765
DOI : 10.1016/j.neubiorev.2015.08.015
PMID : 26321590

Journal ISSN

0149-7634

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13/10/2015 15:22:00

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12/03/2025 09:48:24

Bipolar disorder: Functional neuroimaging markers in relatives

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation