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Title

The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype

Authors
O’Connor, Patrick B. F.
Baranov, Pavel V.
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Published in BMC Genomics. 2015, vol. 16, no. 1, p. 986
Abstract The genetic program, as manifested as the cellular phenotype, is in large part dictated by the cell's protein composition. Since characterisation of the proteome remains technically laborious it is attractive to define the genetic expression profile using the transcriptome. However, the transcriptional landscape is complex and it is unclear as to what extent it reflects the ribosome associated mRNA population (the translatome). This is particularly pertinent for genes using multiple transcriptional start sites (TSS) generating mRNAs with heterogeneous 5' transcript leaders (5'TL). Furthermore, the relative abundance of the TSS gene variants is frequently cell-type specific. Indeed, promoter switches have been reported in pathologies such as cancer. The consequences of this 5'TL heterogeneity within the transcriptome for the translatome remain unresolved. This is not a moot point because the 5'TL plays a key role in regulating mRNA recruitment onto polysomes.
Identifiers
PMID: 26589636
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Research groups Régulation traductionnelle dans les cellules de mammifère (631)
Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
Project FNS: Ligue Genevoise contre le cancer
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DIEUDONNE, François-Xavier et al. The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype. In: BMC Genomics, 2015, vol. 16, n° 1, p. 986. https://archive-ouverte.unige.ch/unige:78593

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Deposited on : 2015-12-14

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