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Free accessOther version: http://www.nature.com/doifinder/10.1038/ng.3042
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Scientific Article
unige:78452 
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The common marmoset genome provides insight into primate biology and evolution |
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| Author | ||
| Collaboration | With : Gerlach, Daniel / Kriventseva, Evgenia / Zdobnov, Evgeny | |
| Published in | Nature Genetics. 2014, vol. 46, no. 8, p. 850-857 | |
| Abstract | We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. | |
| Keywords | Amino Acid Sequence — Animals — Callithrix/genetics — Evolution — Molecular — Female — Genome — MicroRNAs/genetics — Molecular Sequence Data — Phylogeny — Polymorphism — Single Nucleotide — Reproduction/genetics — Sequence Analysis — DNA/methods | |
| Identifiers | DOI: 10.1038/ng.3042 PMID: 25038751 | |
| Full text |
Article (Published version) (688 Kb) - Free access Other version: http://www.nature.com/doifinder/10.1038/ng.3042 |
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| Structures | ||
| Research group | Génomique Evolutionnaire Computationnelle (830) | |
| Citation (ISO format) | WORLEY, Kim C. The common marmoset genome provides insight into primate biology and evolution. In: Nature Genetics, 2014, vol. 46, n° 8, p. 850-857. https://archive-ouverte.unige.ch/unige:78452 |
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