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The common marmoset genome provides insight into primate biology and evolution

Worley, Kim C
CollaborationWith : Gerlach, Daniel / Kriventseva, Evgenia / Zdobnov, Evgeny
Published in Nature Genetics. 2014, vol. 46, no. 8, p. 850-857
Abstract We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmosetwas assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparisonwith the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the uniquebiology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism.We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex Igenes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways).In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution.This genome sequence for a New World monkey enables increased power for comparative analyses among available primategenomes and facilitates biomedical research application.
Keywords Amino Acid SequenceAnimalsCallithrix/geneticsEvolutionMolecularFemaleGenomeMicroRNAs/geneticsMolecular Sequence DataPhylogenyPolymorphismSingle NucleotideReproduction/geneticsSequence AnalysisDNA/methods
PMID: 25038751
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Research group Génomique Evolutionnaire Computationnelle (830)
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WORLEY, Kim C. The common marmoset genome provides insight into primate biology and evolution. In: Nature Genetics, 2014, vol. 46, n° 8, p. 850-857. doi: 10.1038/ng.3042 https://archive-ouverte.unige.ch/unige:78452

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Deposited on : 2015-12-09

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