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Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals

Published inPLoS neglected tropical diseases, vol. 8, no. 2, e2689
Publication date2014
Abstract

The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas disease. These observations suggested that sirtuins from this parasite (TcSir2rp1 and TcSir2rp3) could play an important role in the regulation of the parasitic cell cycle. Thus, their inhibition could be exploited for the development of novel anti-trypanosomal compounds.

Citation (ISO format)
SACCONNAY, Lionel et al. Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals. In: PLoS neglected tropical diseases, 2014, vol. 8, n° 2, p. e2689. doi: 10.1371/journal.pntd.0002689
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ISSN of the journal1935-2727
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