Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals

Sacconnay, Lionel; Angleviel, Mélissa; Randazzo, Giuseppe Marco; Ferreira Queiroz, Marcos Marcal; Ferreira Queiroz, Emerson; Wolfender, Jean-Luc; Carrupt, Pierre-Alain; Nurisso, Alessandra

doi:10.1371/journal.pntd.0002689

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Title		Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals
Authors		Sacconnay, Lionel Angleviel, Mélissa Randazzo, Giuseppe Marco Ferreira Queiroz, Marcos Marcal Ferreira Queiroz, Emerson Wolfender, Jean-Luc Carrupt, Pierre-Alain Nurisso, Alessandra
Published in		PLOS Neglected Tropical Diseases. 2014, vol. 8, no. 2, e2689
Abstract		The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas disease. These observations suggested that sirtuins from this parasite (TcSir2rp1 and TcSir2rp3) could play an important role in the regulation of the parasitic cell cycle. Thus, their inhibition could be exploited for the development of novel anti-trypanosomal compounds.
Identifiers		DOI: 10.1371/journal.pntd.0002689
Full text		Article (Published version) (6 MB) - Free access Other version: http://dx.plos.org/10.1371/journal.pntd.0002689
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		SACCONNAY, Lionel et al. Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals. In: PLOS Neglected Tropical Diseases, 2014, vol. 8, n° 2, p. e2689. doi: 10.1371/journal.pntd.0002689 https://archive-ouverte.unige.ch/unige:77965