Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals

Article Article scientifique Article Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals eng 2014 author Sacconnay Lionel 771809 author Angleviel Mélissa 797302 author Randazzo Giuseppe Marco 796064 author Ferreira Queiroz Marcos Marcal 773216 author Ferreira Queiroz Emerson 135675 author Wolfender Jean-Luc 135649 author Carrupt Pierre-Alain 135654 author Nurisso Alessandra 727149 e2689 10.1371/journal.pntd.0002689 1935-2727 http://dx.plos.org/10.1371/journal.pntd.0002689 The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas disease. These observations suggested that sirtuins from this parasite (TcSir2rp1 and TcSir2rp3) could play an important role in the regulation of the parasitic cell cycle. Thus, their inhibition could be exploited for the development of novel anti-trypanosomal compounds. Dewey 615 31 Section des sciences pharmaceutiques 17 false PLoS neglected tropical diseases 8 2 41c8c651-b795-4641-80fd-a77aafe515bd Article (Published version) Public journal.pntd.0002689.PDF 6321884 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals	PLoS neglected tropical diseases			2014	659	286

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Angleviel, Mélissa