en
Scientific article
English

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

Published inScience, vol. 348, no. 6238, p. 1031-1035
Publication date2015
Abstract

Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD.

Keywords
  • Animals
  • Apoptosis/immunology
  • Autoimmunity
  • Bacteria/immunology
  • CD4-Positive T-Lymphocytes/immunology
  • Colon/microbiology
  • Female
  • Flagellin/genetics/immunology
  • Histocompatibility Antigens Class II/immunology
  • Humans
  • Immunity, Innate
  • Inflammatory Bowel Diseases/immunology/microbiology
  • Lymphocyte Activation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Symbiosis
  • Thymus Gland/immunology
Citation (ISO format)
HEPWORTH, Matthew R et al. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. In: Science, 2015, vol. 348, n° 6238, p. 1031–1035. doi: 10.1126/science.aaa4812
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0036-8075
549views
6downloads

Technical informations

Creation10/08/2015 1:35:00 PM
First validation10/08/2015 1:35:00 PM
Update time03/14/2023 11:53:45 PM
Status update03/14/2023 11:53:44 PM
Last indexation01/16/2024 7:39:03 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack