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Optogenetic dissection of neural circuitry: from synaptic causalities to blue prints for novel treatments of behavioral diseases

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Published in Current Opinion in Neurobiology. 2015, vol. 35, p. 95-100
Abstract Optogenetics has enabled the characterization of the neural circuits involved in brain diseases, such as addiction, depression or obsessive compulsive disorders. Recently, the technique has also been used to propose blueprints for novel treatments aiming at restoring circuit function through the reversal of specific forms of synaptic plasticity. Since optogenetic manipulations cannot be immediately translated to human use, we argue that an intermediate strategy could consist of emulating optogenetic protocols with deep brain stimulation (DBS). This translational path to rational, optogenetically inspired DBS protocols starts by refining existing approaches and carries the hope to expand to novel indications.
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PMID: 26264408
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Article (Published version) (736 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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LUSCHER, Christian, PASCOLI, Vincent Jean, CREED, Meaghan. Optogenetic dissection of neural circuitry: from synaptic causalities to blue prints for novel treatments of behavioral diseases. In: Current Opinion in Neurobiology, 2015, vol. 35, p. 95-100. https://archive-ouverte.unige.ch/unige:77670

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Deposited on : 2015-11-25

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