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Unravelling the target specificity of the major AGC kinases in Saccharomyces cerevisiae

Defense Thèse de doctorat : Univ. Genève, 2015 - Sc. 4829 - 2015/09/25
Abstract To achieve a coordinated growth yeast cells have intimately linked signaling pathways that sense and transduce nutrient and stress signals to adjust different growth-determining processes in the cell. Of central importance to these signaling pathways are AGC family kinases, which play essential roles in many signaling pathways. Out of twenty AGC kinases in Saccharomyces cerevisiae, six are of particular importance since they are integrated in the major growth controlling network. Sch9, Ypk1, Ypk2 and PKA AGC kinases contribute to the control of cell growth, they must communicate with each other and through common targets. There is no consensus on how this is achieved. The main goal of this research is to study the target specificity and possible interactions of Tpk1, Tpk2, Tpk3, Sch9, and Ypk1 AGC kinases using a label free mass spectrometry approach. Analysis of the acquired phosphoproteomics data revealed new and known targets of these kinases and, in particular, we were able to identify the first common target between Ypk1 and PKA kinases.
Keywords Sch9PKAYpk1AGC kinasesPhosphoproteomics
URN: urn:nbn:ch:unige-770350
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Research group Groupe Loewith
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PEREPELKINA, Mariya. Unravelling the target specificity of the major AGC kinases in Saccharomyces cerevisiae. Université de Genève. Thèse, 2015. doi: 10.13097/archive-ouverte/unige:77035 https://archive-ouverte.unige.ch/unige:77035

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Deposited on : 2015-11-09

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