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Title

Unravelling the target specificity of the major AGC kinases in Saccharomyces cerevisiae
Author
Perepelkina, Mariya
Director
Loewith, Robbie Joséph
Defense Thèse de doctorat : Univ. Genève, 2015 - Sc. 4829 - 2015/09/25
Abstract To achieve a coordinated growth yeast cells have intimately linked signaling pathways that sense and transduce nutrient and stress signals to adjust different growth-determining processes in the cell. Of central importance to these signaling pathways are AGC family kinases, which play essential roles in many signaling pathways. Out of twenty AGC kinases in Saccharomyces cerevisiae, six are of particular importance since they are integrated in the major growth controlling network. Sch9, Ypk1, Ypk2 and PKA AGC kinases contribute to the control of cell growth, they must communicate with each other and through common targets. There is no consensus on how this is achieved. The main goal of this research is to study the target specificity and possible interactions of Tpk1, Tpk2, Tpk3, Sch9, and Ypk1 AGC kinases using a label free mass spectrometry approach. Analysis of the acquired phosphoproteomics data revealed new and known targets of these kinases and, in particular, we were able to identify the first common target between Ypk1 and PKA kinases.
Keywords Sch9 — PKA — Ypk1 — AGC kinases — Phosphoproteomics
Identifiers
URN: urn:nbn:ch:unige-770350
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Thesis (3.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section de biologie / Département de biologie moléculaire
Research group Groupe Loewith
Citation
(ISO format) 		PEREPELKINA, Mariya. Unravelling the target specificity of the major AGC kinases in Saccharomyces cerevisiae. Université de Genève. Thèse, 2015. doi: 10.13097/archive-ouverte/unige:77035 https://archive-ouverte.unige.ch/unige:77035

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Deposited on : 2015-11-09

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