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Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions |
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Authors | ||
Published in | AIDS. 2004, vol. 18, no. 14, p. 1951-1953 | |
Abstract | In HIV-1-infected patients with long-term undetectable viraemia on highly active antiretroviral treatment (HAART), we found that pre-HAART plasma viraemia and the baseline proviral DNA level were significantly associated with the viraemia setpoint during scheduled treatment interruptions. In long-term treated patients, pre-HAART viraemia may not be available, and in these circumstances proviral DNA, measured at the time of scheduled treatment interruption, can help to identify patients likely to reach a low viraemia setpoint after treatment interruption. | |
Keywords | Antiretroviral Therapy, Highly Active — Cohort Studies — DNA, Viral — HIV Infections/drug therapy/ genetics/virology — HIV-1/ genetics — Humans — Multivariate Analysis — Mutation/genetics — RNA, Viral/genetics — Viremia/genetics/virology | |
Identifiers | PMID: 15353981 | |
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Citation (ISO format) | YERLY FERRILLO, Sabine et al. Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions. In: AIDS, 2004, vol. 18, n° 14, p. 1951-1953. doi: 10.1097/00002030-200409240-00011 https://archive-ouverte.unige.ch/unige:7698 |