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Title

Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions
Authors
Yerly Ferrillo, Sabine
Gunthard, Huldrych
Fagard, Catherine
Joos, Beda
Perneger, T. V.
Hirschel, Bernard
Perrin, Luc
Published in AIDS. 2004, vol. 18, no. 14, p. 1951-1953
Abstract In HIV-1-infected patients with long-term undetectable viraemia on highly active antiretroviral treatment (HAART), we found that pre-HAART plasma viraemia and the baseline proviral DNA level were significantly associated with the viraemia setpoint during scheduled treatment interruptions. In long-term treated patients, pre-HAART viraemia may not be available, and in these circumstances proviral DNA, measured at the time of scheduled treatment interruption, can help to identify patients likely to reach a low viraemia setpoint after treatment interruption.
Keywords Antiretroviral Therapy, Highly Active — Cohort Studies — DNA, Viral — HIV Infections/drug therapy/ genetics/virology — HIV-1/ genetics — Humans — Multivariate Analysis — Mutation/genetics — RNA, Viral/genetics — Viremia/genetics/virology
Identifiers
PMID: 15353981
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00002030-200409240-00011&LSLINK=80&D=ovft
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Citation
(ISO format) 		YERLY FERRILLO, Sabine et al. Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions. In: AIDS, 2004, vol. 18, n° 14, p. 1951-1953. doi: 10.1097/00002030-200409240-00011 https://archive-ouverte.unige.ch/unige:7698

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Deposited on : 2010-06-21

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