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Title

Absence of chronic human immunodeficiency virus infection without seroconversion in intravenous drug users: a prospective and retrospective study

Authors
Chamot, E.
Published in The Journal of Infectious Diseases. 1991, vol. 164, no. 5, p. 965-968
Abstract It has been reported that human immunodeficiency virus type 1 (HIV-1) infection may exist in persons without specific antibodies for years. To measure the frequency of a silent carrier state, a study was conducted in a cohort of 124 intravenous drug users (IVDUs) without anti-HIV-1 antibodies. All the participants had engaged in high-risk behavior for HIV-1 transmission for a number of years until 1987 or later. Samples were analyzed at 6-month intervals for the presence of HIV-1 provirus using DNA amplification and for the appearance of anti-HIV-1 antibodies. HIV-1 provirus and antibodies were undetectable in 122 participants, whereas seroconversion was observed in 2. In one of these, both amplified HIV-1 pol gene segment and anti-HIV-1 antibodies were detected simultaneously, and in the other, provirus was detected 1 month before seroconversion. This study suggests that long-term HIV-1 infection without anti-HIV-1 antibodies is rare and that repeated antibody testing is sufficient to determine the HIV-1 status of a person no longer at high risk for HIV-1 infection.
Keywords AdultBlotting, SouthernCarrier State/ diagnosisCohort StudiesDNA, Viral/analysisFemaleFollow-Up StudiesHIV Antibodies/bloodHIV Infections/ diagnosis/etiologyHIV-1/genetics/immunology/ isolation & purificationHumansImmunoblottingMalePolymerase Chain ReactionProspective StudiesRetrospective StudiesSubstance Abuse, Intravenous/ complications
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PMID: 1940476
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YERLY FERRILLO, Sabine et al. Absence of chronic human immunodeficiency virus infection without seroconversion in intravenous drug users: a prospective and retrospective study. In: The Journal of Infectious Diseases, 1991, vol. 164, n° 5, p. 965-968. doi: 10.1093/infdis/164.5.965 https://archive-ouverte.unige.ch/unige:7696

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Deposited on : 2010-06-21

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