Scientific article
English

Exploiting the phase of NMR signals to carry useful information. Application to the measurement of chemical shifts in aliased 2D spectra

Published inMagnetic resonance in chemistry, vol. 53, no. 11, p. 901-907
Publication date2015
Abstract

Taking advantage of the phase of nuclear magnetic resonance (NMR) signals to encode NMR information is not easy because of their low precision and their sensitivity to nearby signals. We nevertheless demonstrated that the phase in indirect dimension of 1H–13C heteronuclear single quantum coherence (HSQC) signals could provide carbon chemical shifts at low, but sufficient precision to resolve the ambiguities of the chemical shifts in aliased spectra. This approach, we called phase-encoding of the aliasing order Na (PHANA), only requires inserting a constant delay during the t1 evolution time to obtain spectra where signals with mixed phases can be decoded at the processing to reconstruct full spectra with a 15-fold increase in resolution

Keywords
  • NMR
  • 13C
  • 1H
  • HSQC
  • Fast method
  • Spectral aliasing
  • Phase coding of chemical shifts
  • PHANA
  • Cyclosporine A
Notehttps://arxiv.org/submit/1914274
Research groups
Citation (ISO format)
RAMIREZ GUALITO, Karla Elizabeth, JEANNERAT, Damien. Exploiting the phase of NMR signals to carry useful information. Application to the measurement of chemical shifts in aliased 2D spectra. In: Magnetic resonance in chemistry, 2015, vol. 53, n° 11, p. 901–907. doi: 10.1002/mrc.4301
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ISSN of the journal0749-1581
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