Exploiting the phase of NMR signals to carry useful information. Application to the measurement of chemical shifts in aliased 2D spectra

Article Article scientifique Article Exploiting the phase of NMR signals to carry useful information. Application to the measurement of chemical shifts in aliased 2D spectra eng 2015 author Ramirez Gualito Karla Elizabeth 785069 author Jeannerat Damien 45489 901-907 10.1002/mrc.4301 0749-1581 1914274 Taking advantage of the phase of nuclear magnetic resonance (NMR) signals to encode NMR information is not easy because of their low precision and their sensitivity to nearby signals. We nevertheless demonstrated that the phase in indirect dimension of 1H–13C heteronuclear single quantum coherence (HSQC) signals could provide carbon chemical shifts at low, but sufficient precision to resolve the ambiguities of the chemical shifts in aliased spectra. This approach, we called phase-encoding of the aliasing order Na (PHANA), only requires inserting a constant delay during the t1 evolution time to obtain spectra where signals with mixed phases can be decoded at the processing to reconstruct full spectra with a 15-fold increase in resolution https://arxiv.org/submit/1914274 NMR 13C 1H HSQC Fast method Spectral aliasing Phase coding of chemical shifts PHANA Cyclosporine A Dewey 540 36 Département de chimie organique 141 false 764 Groupe Jeannerat Magnetic resonance in chemistry 53 11 8181bfea-92c2-459d-8af1-3ee06e95ec88 Article (Published version) Restricted Ram-rez-Gualito_et_al-2015-Magnetic_Resonance_in_Chemistry.pdf 1543044 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

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Exploiting the phase of NMR signals to carry useful information. Application to the measurement of chemical shifts in aliased 2D spectra	Magnetic resonance in chemistry			2015	709	3

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Ramirez Gualito, Karla Elizabeth