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Title

Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury
Authors
Van De Looij, Yohan
Dean, Justin
Gunn, Alistair J
Hüppi, Petra Susan
Sizonenko, Stéphane
Published in International Journal of Developmental Neuroscience. 2015, vol. 45, p. 29-38
Abstract Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are widely used in the field of brain development and perinatal brain injury. Due to technical progress the magnetic field strength (B0) of MR systems has continuously increased, favoring (1)H-MRS with quantification of up to 18 metabolites in the brain and short echo time (TE) MRI sequences including phase and susceptibility imaging. For longer TE techniques including diffusion imaging modalities, the benefits of higher B0 have not been clearly established. Nevertheless, progress has also been made in new advanced diffusion models that have been developed to enhance the accuracy and specificity of the derived diffusion parameters. In this review, we will describe the latest developments in MRS and MRI techniques, including high-field (1)H-MRS, phase and susceptibility imaging, and diffusion imaging, and discuss their application in the study of cerebral development and perinatal brain injury.
Identifiers
PMID: 25818582
Full text
Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group L'imagerie cérébrale (184)
Citation
(ISO format) 		VAN DE LOOIJ, Yohan et al. Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury. In: International Journal of Developmental Neuroscience, 2015, vol. 45, p. 29-38. doi: 10.1016/j.ijdevneu.2015.03.009 https://archive-ouverte.unige.ch/unige:76383

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Deposited on : 2015-10-22

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