Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship

Vanhems, P.; Lambert, J.; Cooper, David; Perrin, Luc; Carr, A.; Hirschel, Bernard; Vizzard, J.; Kinloch-de Loes, S.; Allard, Robert

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Title		Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship
Authors		Vanhems, P. Lambert, J. Cooper, David Perrin, Luc Carr, A. Hirschel, Bernard Vizzard, J. Kinloch-de Loes, S. Allard, Robert show all authors [1 - 9]
Published in		Clinical Infectious Diseases. 1998, vol. 26, no. 2, p. 323-329
Abstract		This study examined the relationship between the severity of acute human immunodeficiency virus type 1 (HIV-1) illness and disease progression and death. The population included 218 patients with acute HIV-1 illness and 41 asymptomatic patients who underwent HIV-1 seroconversion; the patients were followed up prospectively. We analyzed progression to Centers for Disease Control and Prevention clinical categories B and C (AIDS-defining conditions) and death according to an additive clinical score (CS) based on six predictive clinical features at the time of acute HIV-1 infection. Compared with patients with a CS of 0 (asymptomatic patients), those with a CS of 3-4 and 5-6 had faster progression to category B disease (adjusted hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.01-1.92; and HR, 1.80; 95% CI, 1.34-2.40; respectively); those with a CS of 5-6 had faster progression to category C disease (HR, 1.37; 95% CI, 1.01-1.89) and death (HR, 2.05; 95% CI, 1.27-3.32). Thus, the number of symptoms and signs at the time of acute HIV-1 illness affects disease progression and survival, even in symptomatic patients who have undergone seroconversion.
Keywords		Acute Disease — Adult — Female — Follow-Up Studies — HIV Infections/immunology/ physiopathology/virology — Hiv-1 — Humans — Male — Prognosis — Prospective Studies — Risk Factors — Severity of Illness Index
Identifiers		PMID: 9502449
Full text		Article - Limited access to UNIGE Other version: http://www.jstor.org/stable/4481353
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		VANHEMS, P. et al. Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship. In: Clinical Infectious Diseases, 1998, vol. 26, n° 2, p. 323-329. https://archive-ouverte.unige.ch/unige:7638