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Title

Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship

Authors
Vanhems, P.
Lambert, J.
Cooper, David
Carr, A.
Vizzard, J.
Kinloch-de Loes, S.
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Published in Clinical Infectious Diseases. 1998, vol. 26, no. 2, p. 323-329
Abstract This study examined the relationship between the severity of acute human immunodeficiency virus type 1 (HIV-1) illness and disease progression and death. The population included 218 patients with acute HIV-1 illness and 41 asymptomatic patients who underwent HIV-1 seroconversion; the patients were followed up prospectively. We analyzed progression to Centers for Disease Control and Prevention clinical categories B and C (AIDS-defining conditions) and death according to an additive clinical score (CS) based on six predictive clinical features at the time of acute HIV-1 infection. Compared with patients with a CS of 0 (asymptomatic patients), those with a CS of 3-4 and 5-6 had faster progression to category B disease (adjusted hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.01-1.92; and HR, 1.80; 95% CI, 1.34-2.40; respectively); those with a CS of 5-6 had faster progression to category C disease (HR, 1.37; 95% CI, 1.01-1.89) and death (HR, 2.05; 95% CI, 1.27-3.32). Thus, the number of symptoms and signs at the time of acute HIV-1 illness affects disease progression and survival, even in symptomatic patients who have undergone seroconversion.
Keywords Acute DiseaseAdultFemaleFollow-Up StudiesHIV Infections/immunology/ physiopathology/virologyHiv-1HumansMalePrognosisProspective StudiesRisk FactorsSeverity of Illness Index
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PMID: 9502449
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Other version: http://www.jstor.org/stable/4481353
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VANHEMS, P. et al. Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship. In: Clinical Infectious Diseases, 1998, vol. 26, n° 2, p. 323-329. https://archive-ouverte.unige.ch/unige:7638

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Deposited on : 2010-06-21

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