The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

Csaki Huttner, Angela; Dayer, Julie-Anne; Yerly Ferrillo, Sabine; Combescure, Christophe; Auderset, Floriane; Desmeules, Jules Alexandre; Eickmann, Markus; Finckh, Axel; Goncalves Cabecinhas, Ana Rita; Hooper, Jay W; Kaya, Guerkan; Krähling, Verena; Kwilas, Steve; Lemaitre, Barbara; Matthey, Alain; Silvera, Peter; Becker, Stephan; Fast, Patricia E; Moorthy, Vasee; Kieny, Marie Paule; Kaiser, Laurent; Siegrist, Claire-Anne

doi:10.1016/S1473-3099(15)00154-1

Scientific article

English

The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

Published inLancet. Infectious diseases, vol. 15, no. 10, p. 1156-1166

Publication date2015

Abstract

Safe and effective vaccines against Ebola could prevent or control outbreaks. The safe use of replication-competent vaccines requires a careful dose-selection process. We report the first safety and immunogenicity results in volunteers receiving 3 × 10(5) plaque-forming units (pfu) of the recombinant vesicular stomatitis virus-based candidate vaccine expressing the Zaire Ebola virus glycoprotein (rVSV-ZEBOV; low-dose vaccinees) compared with 59 volunteers who had received 1 ×10(7) pfu (n=35) or 5 × 10(7) pfu (n=16) of rVSV-ZEBOV (high-dose vaccinees) or placebo (n=8) before a safety-driven study hold.

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Citation (ISO format)

CSAKI HUTTNER, Angela et al. The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial. In: Lancet. Infectious diseases, 2015, vol. 15, n° 10, p. 1156–1166. doi: 10.1016/S1473-3099(15)00154-1

Article (Published version)

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PID : unige:76362
DOI : 10.1016/S1473-3099(15)00154-1
PMID : 26248510

ISSN of the journal1473-3099

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The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

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