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Title

Comprehensive classification of symptoms and signs reported among 218 patients with acute HIV-1 infection

Authors
Vanhems, P.
Dassa, C.
Lambert, J.
Cooper, David
Vizzard, J.
Kinloch-de Loes, S.
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Published in Journal of Acquired Immune Deficiency Syndromes. 1999, vol. 21, no. 2, p. 99-106
Abstract Acute HIV-1 illness presents a wide range of clinical manifestations. We assessed a classification and data reduction of clinical features among 218 patients with acute HIV-1 infection enrolled in four prospective seroincidence studies. Factor analysis allows the definition of eight factors based on groups of symptoms and signs: gastrointestinal transit disturbances, weight loss/abdominal pain, lymphadenopathy, myalgia/arthralgia, neurologic features, constitutional and mucocutaneous features, oral candidiasis, and anorexia/pharyngitis. These groups reflected the main target systems involved at the time of acute HIV-1 disease. Grouping of symptoms and signs based on groups of patients is potentially more informative than observations made on individual patients. It might facilitate diagnosis, suggest pathogenic mechanisms and reduce the number of variables for characterizing acute HIV-1 illness.
Keywords Acute DiseaseAdolescentAdultAnorexiaArthralgiaAustraliaCandidiasis, OralEuropeFactor Analysis, StatisticalFemaleGastrointestinal DiseasesHIV Infections/ classification/ diagnosis/physiopathology/virologyHiv-1HumansLymphatic DiseasesMaleMiddle AgedNervous System DiseasesPharyngitisProspective StudiesRisk FactorsSkin DiseasesWeight Loss
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PMID: 10360800
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VANHEMS, P. et al. Comprehensive classification of symptoms and signs reported among 218 patients with acute HIV-1 infection. In: Journal of Acquired Immune Deficiency Syndromes, 1999, vol. 21, n° 2, p. 99-106. https://archive-ouverte.unige.ch/unige:7633

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Deposited on : 2010-06-21

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