Article - Limited access to UNIGE
Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive?
|Published in||Clinical Infectious Diseases. 1997, vol. 24, no. 5, p. 965-970|
|Abstract||The purpose of this study was to describe the frequency and duration of clinical features at the time of acute human immunodeficiency virus type 1 (HIV-1) disease in 218 patients with documented symptomatic primary HIV-1 infection. The mean duration of acute HIV-1 disease was 25.1 days (median, 20.0 days) and did not differ by gender, age, and risk factor. The frequency and mean duration of clinical features occurring in >50% of patients were as follows: fever, 77.1% and 16.9 days; lethargy, 65.6% and 23.7 days; cutaneous rash, 56.4% and 15 days; myalgia, 54.6% and 17.7 days; and headache, 50.9% and 25.8 days. Only 15.6% of patients presented with a typical mononucleosis-like illness (MLI) defined as fever, pharyngitis or sore throat, and cervical adenopathy, and 10% had no features of an MLI. A meningitis-like syndrome occurred in 20 patients (9.2%). Acute HIV-1 disease is more diverse than previously reported, and the absence of fever or other MLI features does not rule out acute HIV-1 disease.|
|Keywords||Acute Disease — Adult — Cohort Studies — Diagnosis, Differential — Fatigue Syndrome, Chronic/ diagnosis/physiopathology — Female — HIV Infections/ diagnosis/physiopathology — HIV-1/ isolation & purification — Humans — Male — Prognosis — Prospective Studies — Time Factors|
|VANHEMS, P. et al. Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive?. In: Clinical Infectious Diseases, 1997, vol. 24, n° 5, p. 965-970. doi: 10.1093/clinids/24.5.965 https://archive-ouverte.unige.ch/unige:7631|