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Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive?

Vanhems, P.
Allard, Robert
Cooper, David
Vizzard, J.
Kinloch-de Loes, S.
Carr, A.
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Published in Clinical infectious diseases. 1997, vol. 24, no. 5, p. 965-970
Abstract The purpose of this study was to describe the frequency and duration of clinical features at the time of acute human immunodeficiency virus type 1 (HIV-1) disease in 218 patients with documented symptomatic primary HIV-1 infection. The mean duration of acute HIV-1 disease was 25.1 days (median, 20.0 days) and did not differ by gender, age, and risk factor. The frequency and mean duration of clinical features occurring in >50% of patients were as follows: fever, 77.1% and 16.9 days; lethargy, 65.6% and 23.7 days; cutaneous rash, 56.4% and 15 days; myalgia, 54.6% and 17.7 days; and headache, 50.9% and 25.8 days. Only 15.6% of patients presented with a typical mononucleosis-like illness (MLI) defined as fever, pharyngitis or sore throat, and cervical adenopathy, and 10% had no features of an MLI. A meningitis-like syndrome occurred in 20 patients (9.2%). Acute HIV-1 disease is more diverse than previously reported, and the absence of fever or other MLI features does not rule out acute HIV-1 disease.
Keywords Acute DiseaseAdultCohort StudiesDiagnosis, DifferentialFatigue Syndrome, Chronic/ diagnosis/physiopathologyFemaleHIV Infections/ diagnosis/physiopathologyHIV-1/ isolation & purificationHumansMalePrognosisProspective StudiesTime Factors
PMID: 9142802
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VANHEMS, P. et al. Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive?. In: Clinical Infectious Diseases, 1997, vol. 24, n° 5, p. 965-970. doi: 10.1093/clinids/24.5.965 https://archive-ouverte.unige.ch/unige:7631

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Deposited on : 2010-06-21

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