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Title

Reasons for failure of prevention of Toxoplasma encephalitis. Swiss HIV Cohort Study

Authors
Gabriel, V.
Flepp, Markus
von Overbeck, J.
Published in AIDS. 1996, vol. 10, no. 5, p. 509-513
Abstract OBJECTIVE: To study whether absence of prophylaxis is a risk factor for cerebral toxoplasmosis, and to determine the reasons for absence of prophylaxis among AIDS patients diagnosed with Toxoplasma encephalitis (TE). DESIGN: Retrospective chart review and matched case-control study. PATIENTS: Patients (104 first episodes and 26 relapses of TE) were registered in the Swiss HIV Cohort Study from three centres from July 1992 to December 1994; 91 matched controls were included for 52 patients with a first episode, and 17 matched controls for 17 patients with relapse of TE. RESULTS: Prophylaxis was prescribed to 17 patients (16%) with a first episode and 19 patients (73%) with a relapse of TE. Reasons for the absence of prophylaxis included patient refusal (25%), non-proposal by physicians (17%), and drug intolerance (17%). Reduced absorption due to non-compliance, diarrhoea or vomiting was identified among 12 patients with a first episode and 14 patients with a relapse of TE. Absence of prescription of prophylaxis was associated with a 10-fold increased risk of a first episode of TE (odds ratio, 9.8; 95% confidence interval, 2.7-35.4) in the matched case-control study. CONCLUSIONS: TE continues to occur among patients not receiving prophylaxis. At least one-half of the cases may be prevented with better motivation of physicians and increased compliance of patients.
Keywords AIDS-Related Opportunistic Infections/ prevention & controlAdultAntiprotozoal Agents/therapeutic useCohort StudiesEncephalitis/ prevention & controlFemaleHumansMaleMatched-Pair AnalysisRetrospective StudiesRisk FactorsToxoplasmosis, Cerebral/ prevention & control
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PMID: 8724042
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VAN DELDEN, Christian et al. Reasons for failure of prevention of Toxoplasma encephalitis. Swiss HIV Cohort Study. In: AIDS, 1996, vol. 10, n° 5, p. 509-513. https://archive-ouverte.unige.ch/unige:7628

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Deposited on : 2010-06-21

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