UNIGE document Scientific Article
previous document  unige:7595  next document
add to browser collection
Title

Risk factors for tuberculosis among HIV-infected patients in Switzerland. Swiss HIV Cohort Study

Authors
Toscani, L.
Ledergerber, Bruno
Rieder, H. L.
Published in European Respiratory Journal. 1996, vol. 9, no. 2, p. 279-283
Abstract The aim of this study was to determine the risk factors associated with tuberculosis among human immunodeficiency virus (HIV)-infected persons living in Switzerland, a country with low prevalence of tuberculous infection. We performed a nested case-control study and logistic regression. Cases (n = 239) were patients participating in the Swiss-HIV Cohort study (n = 7,103), diagnosed with bacteriologically confirmed tuberculosis. The rest of the cohort population was used as control. Patients from industrialized countries had a risk of tuberculosis similar to those from Switzerland (adjusted odds ratio (OR) 1.1; 95% confidence interval (95% CI) 0.7-1.5); whereas the risk among patients from Eastern Europe (OR 2.8, 95% CI 1.9-3.7), Brazil (OR 10.6; 95% CI 9.6-11.5), and Africa (OR 3.0; 95% CI 2.4-3.6) was markedly higher. Immune suppression, as indicated by low CD4 + cell count, was an independent risk factor for tuberculosis (OR 7.8; 95% CI 7.3-8.3 for patients with CD4 + < 50 cells.mm-3 compared to those with CD4 + > 500 cells.mm-3). Age, sex and HIV-transmission category did not appear to increase the risk of tuberculosis after adjustment for other patient characteristics. In conclusion, in countries of low prevalence of Mycobacterium tuberculosis infection, to originate from a country with high prevalence of tuberculosis infection and to have advanced immunodeficiency are significant risk factors for tuberculosis. They may be used to complement the tuberculin skin test in targeting patients for preventive chemotherapy.
Keywords AdultCase-Control StudiesCohort StudiesFemaleHIV Infections/ complications/diagnosisHumansLogistic ModelsMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsSwitzerland/epidemiologyTuberculosis/complications/diagnosis/ epidemiology
Identifiers
PMID: 8777964
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://erj.ersjournals.com/cgi/reprint/9/2/279.pdf
Structures
Citation
(ISO format)
SUDRE, Philippe et al. Risk factors for tuberculosis among HIV-infected patients in Switzerland. Swiss HIV Cohort Study. In: European Respiratory Journal, 1996, vol. 9, n° 2, p. 279-283. https://archive-ouverte.unige.ch/unige:7595

210 hits

1 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :