Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

Xie, Xiaojiang; Gutierrez, Agustin; Trofimov, Valentin; Szilagyi, Istvan; Soldati, Thierry; Bakker, Eric

doi:10.1021/acs.analchem.5b02566

Scientific article

English

Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

Contributors

Xie, Xiaojiang; Gutierrez, Agustin; Trofimov, Valentin; Szilagyi, Istvan; Soldati, Thierry

; Bakker, Eric

Published in

Analytical chemistry, vol. 87, no. 19, p. 9954-9959

Publication date

2015

Abstract

Ionophore-based ion selective optical nanosensors that operate independently of the sample pH are developed here by the use of electrically charged solvatochromic dyes as signal transducers. A series of dye molecules with a D-π-A structure was synthesized and characterized in various solvents and incorporated into ion selective nanospheres for K+, Na+, and H+. Since dye leakage was greatly suppressed when the solvatochromic dyes were encapsulated in the nanosphere core, ion sensing nanospheres were explored for cellular ion imaging in Dictyostelium discoideum live cells but spontaneous dye loss resulted in undesired staining of cells. The in vitro analysis of potassium in human plasma was successfully demonstrated with this approach. A theoretical model was developed for the response of the ion selective nanosensors containing charged solvatochromic dyes. The nanosensors exhibited a tunable response range, high sensitivity, and good stability.

UNIGE affiliation entities

UNIGE research groups

Groupe Soldati

Citation (ISO format)

XIE, Xiaojiang et al. Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors. In: Analytical chemistry, 2015, vol. 87, n° 19, p. 9954–9959. doi: 10.1021/acs.analchem.5b02566

Article (Published version)

Identifiers

PID : unige:75925
DOI : 10.1021/acs.analchem.5b02566

Journal ISSN

0003-2700

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09/10/2015 15:10:00

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09/10/2015 15:10:00

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14/03/2023 23:41:34

Status update

14/03/2023 23:41:34

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31/10/2024 01:30:24

Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation