Scientific article

Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS

Publication date2004

There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.

  • Acquired Immunodeficiency Syndrome/ etiology/genetics/ immunology
  • Adult
  • Aged
  • Alleles
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Genes, MHC Class I
  • HLA Antigens/genetics
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Models, Immunological
  • Spain
  • Switzerland
  • T-Lymphocytes, Cytotoxic/ immunology
Citation (ISO format)
SCHERER, Almut et al. Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. In: Proceedings of the National Academy of Sciences of the United States of America, 2004, vol. 101, n° 33, p. 12266–12270. doi: 10.1073/pnas.0404091101
Updates (1)
ISSN of the journal0027-8424

Technical informations

Creation06/21/2010 10:26:21 AM
First validation06/21/2010 10:26:21 AM
Update time03/14/2023 3:45:31 PM
Status update03/14/2023 3:45:31 PM
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