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Title

Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS

Authors
Scherer, Almut
Frater, A. John
Oxenius, Annette
Agudelo, Juliet
Price, D. A.
Gunthard, Huldrych
Barnardo, Martin
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Published in Proceedings of the National Academy of Sciences. 2004, vol. 101, no. 33, p. 12266-12270
Abstract There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.
Keywords Acquired Immunodeficiency Syndrome/ etiology/genetics/ immunologyAdultAgedAllelesCohort StudiesCross-Sectional StudiesFemaleGenes, MHC Class IHLA Antigens/geneticsHumansLongitudinal StudiesMaleMiddle AgedModels, ImmunologicalSpainSwitzerlandT-Lymphocytes, Cytotoxic/ immunology
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PMID: 15302942
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SCHERER, Almut et al. Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. In: Proceedings of the National Academy of Sciences, 2004, vol. 101, n° 33, p. 12266-12270. https://archive-ouverte.unige.ch/unige:7573

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Deposited on : 2010-06-21

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