UNIGE document Scientific Article
previous document  unige:7561  next document
add to browser collection
Title

Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study

Authors
Samlowski, W. E.
Kuebler, P. J.
Kolodziej, M. A.
Medina, J. E.
Mangan, K. F.
Schuller, D. E.
show hidden authors show all authors [1 - 9]
Published in Investigational New Drugs. 1998, vol. 16, no. 3, p. 271-274
Abstract A phase II trial of Tomudex (raltitrexed, ZD 1694), a new thymidylate synthase inhibitor, was performed in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. This trial demonstrated that Tomudex was well tolerated in this patient population. Nausea and vomiting were minimal, and hematologic toxicities were relatively infrequent. Only one patient was withdrawn from the study due to toxicity (grade 4 diarrhea). One patient exsanguinated from a rent in the carotid artery in an area of tumor involvement, and was categorized as a grade 5 toxicity. Thus 25/27 patients were able to complete at least 2 cycles of treatment. Tomudex demonstrated a 3.7% response rate (95% CI 0.1-19%), with a median survival of 6 months in this highly resistant disease population. Tomudex is not considered active enough as monotherapy for further evaluation in this disease population.
Keywords AgedAntimetabolites, Antineoplastic/ therapeutic useCarcinoma, Squamous Cell/ drug therapy/secondaryFemaleHead and Neck Neoplasms/ drug therapy/pathologyHumansMaleMiddle AgedNeoplasm Recurrence, Local/ drug therapyQuinazolines/ therapeutic useSurvival AnalysisThiophenes/ therapeutic use
Identifiers
PMID: 10360608
Full text
Structures
Citation
(ISO format)
SAMLOWSKI, W. E. et al. Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study. In: Investigational New Drugs, 1998, vol. 16, n° 3, p. 271-274. https://archive-ouverte.unige.ch/unige:7561

171 hits

0 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :