Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study

Article Article scientifique Article Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study eng 1998 author Samlowski W. E. author Lew Daniel Pablo 26516 author Kuebler P. J. author Kolodziej M. A. author Medina J. E. author Mangan K. F. author Moore David Jeffrey 28212 author Schuller D. E. author Ensley J. F. 271-274 10360608 0167-6997 http://www.springerlink.com/content/j2q07574q4587825/fulltext.pdf A phase II trial of Tomudex (raltitrexed, ZD 1694), a new thymidylate synthase inhibitor, was performed in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. This trial demonstrated that Tomudex was well tolerated in this patient population. Nausea and vomiting were minimal, and hematologic toxicities were relatively infrequent. Only one patient was withdrawn from the study due to toxicity (grade 4 diarrhea). One patient exsanguinated from a rent in the carotid artery in an area of tumor involvement, and was categorized as a grade 5 toxicity. Thus 25/27 patients were able to complete at least 2 cycles of treatment. Tomudex demonstrated a 3.7% response rate (95% CI 0.1-19%), with a median survival of 6 months in this highly resistant disease population. Tomudex is not considered active enough as monotherapy for further evaluation in this disease population. Aged Antimetabolites, Antineoplastic/ therapeutic use Carcinoma, Squamous Cell/ drug therapy/secondary Female Head and Neck Neoplasms/ drug therapy/pathology Humans Male Middle Aged Neoplasm Recurrence, Local/ drug therapy Quinazolines/ therapeutic use Survival Analysis Thiophenes/ therapeutic use Dewey 616 56 Département de médecine 221 false Investigational new drugs 16 3 26dab5b9-d72a-4eff-a200-5fb107769902 Article Restricted file1.pdf 53125 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Moore, David Jeffrey