E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

L'Huillier, Arnaud; Abed, Yacine; Petty, Tom; Cordey, Samuel; Thomas, Yves; Bouhy, Xavier; Schibler, Manuel; Simon, Audrey; Chalandon, Yves; Van Delden, Christian; Zdobnov, Evgeny; Boquete-Suter, Patricia; Boivin, Guy; Kaiser, Laurent

doi:10.1093/infdis/jiv288

Scientific article

English

E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

ContributorsL'Huillier, Arnaud

; Abed, Yacine; Petty, Tom; Cordey, Samuel; Thomas, Yves; Bouhy, Xavier; Schibler, Manuel; Simon, Audrey; Chalandon, Yves; Van Delden, Christian; Zdobnov, Evgeny; Boquete-Suter, Patricia; Boivin, Guy; Kaiser, Laurent

Published inThe Journal of infectious diseases, vol. 212, no. 11, p. 1726-1734

Publication date2015

Abstract

An influenza A(H1N1)pdm09 infection was diagnosed in a hematopoietic stem cell transplant recipient during conditioning regimen. He was treated with oral oseltamivir, later combined with intravenous zanamivir. The H275Y neuraminidase (NA) mutation was first detected, and an E119D NA mutation was identified during zanamivir therapy.

Affiliation entities

Research groups

Citation (ISO format)

L’HUILLIER, Arnaud et al. E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient. In: The Journal of infectious diseases, 2015, vol. 212, n° 11, p. 1726–1734. doi: 10.1093/infdis/jiv288

Identifiers

PID : unige:75570
DOI : 10.1093/infdis/jiv288
PMID : 25985905

Journal ISSN0022-1899

721views

0downloads

Creation20/07/2015 15:10:00

First validation20/07/2015 15:10:00

Update time08/11/2024 08:34:12

Status update08/11/2024 08:34:12

Last indexation19/11/2024 15:02:46

Archive ouverte UNIGE

E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

Technical informations