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Title

E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

Authors
Abed, Yacine
Petty, Tom
Bouhy, Xavier
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Published in The Journal of Infectious Diseases. 2015, vol. 212, no. 11, p. 1726-1734
Abstract An influenza A(H1N1)pdm09 infection was diagnosed in a hematopoietic stem cell transplant recipient during conditioning regimen. He was treated with oral oseltamivir, later combined with intravenous zanamivir. The H275Y neuraminidase (NA) mutation was first detected, and an E119D NA mutation was identified during zanamivir therapy.
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PMID: 25985905
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Structures
Research groups Groupe Laurent Kaiser (virologie clinique) (668)
Génomique Evolutionnaire Computationnelle (830)
Quorom-sensing et gènes de virulence (301)
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L'HUILLIER, Arnaud et al. E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient. In: The Journal of Infectious Diseases, 2015, vol. 212, n° 11, p. 1726-1734. https://archive-ouverte.unige.ch/unige:75570

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Deposited on : 2015-10-01

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