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E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

ContributorsL'Huillier, Arnaudorcid; Abed, Yacine; Petty, Tom; Cordey, Samuel; Thomas, Yves; Bouhy, Xavier; Schibler, Manuel; Simon, Audrey; Chalandon, Yvesorcid; Van Delden, Christian; Zdobnov, Evgeny; Boquete-Suter, Patricia; Boivin, Guy; Kaiser, Laurent
Published inThe Journal of infectious diseases, vol. 212, no. 11, p. 1726-1734
Publication date2015
Abstract

An influenza A(H1N1)pdm09 infection was diagnosed in a hematopoietic stem cell transplant recipient during conditioning regimen. He was treated with oral oseltamivir, later combined with intravenous zanamivir. The H275Y neuraminidase (NA) mutation was first detected, and an E119D NA mutation was identified during zanamivir therapy.

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Citation (ISO format)
L’HUILLIER, Arnaud et al. E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient. In: The Journal of infectious diseases, 2015, vol. 212, n° 11, p. 1726–1734. doi: 10.1093/infdis/jiv288
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Journal ISSN0022-1899
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Creation20/07/2015 15:10:00
First validation20/07/2015 15:10:00
Update09/02/2026 15:37:23
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