UNIGE document Scientific Article
previous document  unige:7557  next document
add to browser collection
Title

Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV

Authors
Anwar, D.
Perrin, L. H.
Published in The Journal of Infectious Diseases. 1998, vol. 177, no. 3, p. 783-785
Abstract The impact of human immunodeficiency virus (HIV) protease inhibitors on hepatitis C (HCV) viremia was assessed in 19 patients infected with both HIV and HCV. HIV and HCV RNA levels were measured before and during treatment with protease inhibitors. Before treatment, mean levels of HCV RNA were 5.3 log for HCV RNA and 5.0 log for HIV RNA. CD4 lymphocyte counts were 63/mm3. After 6 weeks of treatment, a mean reduction of 2.1 log10 in HIV RNA (P <.001) and a mean (+/-SE) increase of 73 (+/-21) CD4 and 296 (+/-70) CD8 cells were observed (P <.05). In contrast, both HCV viremia (+0.4 log +/- 0.1) and alanine aminotransferase increased (P <.04). HCV RNA levels returned to baseline after 17 and 32 weeks of treatment. Thus, potent anti-HIV regimens with protease inhibitors may temporarily worsen HCV status despite improvement of HIV parameters.
Keywords Anti-HIV Agents/ therapeutic useDrug Therapy, CombinationFemaleHIV Infections/complications/ drug therapyHIV Protease Inhibitors/ therapeutic useHepatitis C/blood/complications/ drug therapyHumansIndinavir/therapeutic useMaleReverse Transcriptase Inhibitors/therapeutic useRitonavir/therapeutic useSaquinavir/therapeutic useViremia/complications/ drug therapy
Identifiers
PMID: 9498464
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.journals.uchicago.edu/doi/pdf/10.1086/517808
Structures
Citation
(ISO format)
RUTSCHMANN, Olivier Thierry et al. Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV. In: The Journal of Infectious Diseases, 1998, vol. 177, n° 3, p. 783-785. https://archive-ouverte.unige.ch/unige:7557

201 hits

0 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :