UNIGE document Scientific Article
previous document  unige:7535  next document
add to browser collection
Title

Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study

Authors
Rauch, Andri
Rickenbach, Martin
Weber, Rainer
Tarr, P. E.
Bucher, H. C.
Vernazza, Pietro
show hidden authors show all authors [1 - 11]
Published in Clinical Infectious Diseases. 2005, vol. 41, no. 3, p. 395-402
Abstract BACKGROUND: Data on the incidence of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected persons are sparse. It is controversial whether and how frequently HCV is transmitted by unprotected sexual intercourse. METHODS: We assessed the HCV seroprevalence and incidence of HCV infection in the Swiss HIV Cohort Study between 1988 and 2004. We investigated the association of HCV seroconversion with mode of HIV acquisition, sex, injection drug use (IDU), and constancy of condom use. Data on condom use or unsafe sexual behavior were prospectively collected between 2000 and 2004. RESULTS: The overall seroprevalence of HCV infection was 33% among a total of 7899 eligible participants and 90% among persons reporting IDU. We observed 104 HCV seroconversions among 3327 participants during a total follow-up time of 16,305 person-years, corresponding to an incidence of 0.64 cases per 100 person-years. The incidence among participants with a history of IDU was 7.4 cases per 100 person-years, compared with 0.23 cases per 100 person-years in patients without such a history (P<.001). In men who had sex with men (MSM) without a history of IDU who reported unsafe sex, the incidence was 0.7 cases per 100 person-years, compared with 0.2 cases per 100 person-years in those not reporting unsafe sex (P=.02), corresponding to an incidence rate ratio of 3.5 (95% confidence interval, 1.2-10.0). The hazard of acquiring HCV infection was elevated among younger participants who were MSM. CONCLUSIONS: HCV infection incidence in the Swiss HIV Cohort Study was mainly associated with IDU. In HIV-infected MSM, HCV infection was associated with unsafe sex.
Keywords AdultCohort StudiesFemaleHIV Infections/ complicationsHepatitis C/ complications/ epidemiologyHomosexuality, MaleHumansIncidenceMalePrevalenceProportional Hazards ModelsRisk FactorsSwitzerland/epidemiologyUnsafe Sex/ statistics & numerical data
Identifiers
PMID: 16007539
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.journals.uchicago.edu/doi/full/10.1086/431486
Structures
Citation
(ISO format)
RAUCH, Andri et al. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. In: Clinical Infectious Diseases, 2005, vol. 41, n° 3, p. 395-402. https://archive-ouverte.unige.ch/unige:7535

211 hits

0 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :