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Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands |
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Published in | Advanced synthesis & catalysis. 2015, vol. 357, no. 13, p. 2833-2839 | |
Abstract | The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields. | |
Keywords | Asymmetric bromine–lithium exchange — Atropoisomeric ligands — Catalytic phosphination — Dihedral angles — Diphosphines | |
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Research group | Groupe Alexakis | |
Citation (ISO format) | GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced synthesis & catalysis, 2015, vol. 357, n° 13, p. 2833-2839. doi: 10.1002/adsc.201500323 https://archive-ouverte.unige.ch/unige:75306 |