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Title

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Authors
Leroux, Frederick
Published in Advanced Synthesis and Catalysis. 2015, vol. 357, no. 13, p. 2833-2839
Abstract The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.
Keywords Asymmetric bromine–lithium exchangeAtropoisomeric ligandsCatalytic phosphinationDihedral anglesDiphosphines
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Article (Published version) (993 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/adsc.201500323
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Research group Groupe Alexakis
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GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced Synthesis and Catalysis, 2015, vol. 357, n° 13, p. 2833-2839. https://archive-ouverte.unige.ch/unige:75306

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Deposited on : 2015-09-22

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