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Title

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands
Authors
Graff, Julien
Lastawiecka, Elzbieta
Guenee, Laure
Leroux, Frederick
Alexakis, Alexandre
Published in Advanced Synthesis and Catalysis. 2015, vol. 357, no. 13, p. 2833-2839
Abstract The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.
Keywords Asymmetric bromine–lithium exchange — Atropoisomeric ligands — Catalytic phosphination — Dihedral angles — Diphosphines
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Article (Published version) (993 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie minérale, analytique et appliquée
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Research group Groupe Alexakis
Citation
(ISO format) 		GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced Synthesis and Catalysis, 2015, vol. 357, n° 13, p. 2833-2839. doi: 10.1002/adsc.201500323 https://archive-ouverte.unige.ch/unige:75306

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Deposited on : 2015-09-22

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