Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Graff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederick; Alexakis, Alexandre

doi:10.1002/adsc.201500323

Scientific article

English

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Contributors

Graff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederick; Alexakis, Alexandre

Published in

Advanced synthesis & catalysis, vol. 357, no. 13, p. 2833-2839

Publication date

2015

Abstract

The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.

Keywords

Asymmetric bromine–lithium exchange
Atropoisomeric ligands
Catalytic phosphination
Dihedral angles
Diphosphines

UNIGE affiliation entities

UNIGE research groups

Groupe Alexakis

Citation (ISO format)

GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced synthesis & catalysis, 2015, vol. 357, n° 13, p. 2833–2839. doi: 10.1002/adsc.201500323

Article (Published version)

Identifiers

PID : unige:75306
DOI : 10.1002/adsc.201500323

Journal ISSN

1615-4150

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2downloads

Creation

17/09/2015 16:00:00

First validation

17/09/2015 16:00:00

Update

14/03/2023 23:37:32

Status update

14/03/2023 23:37:31

Last indexation

31/10/2024 01:17:17

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation