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Scientific article
English

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Published inAdvanced synthesis & catalysis, vol. 357, no. 13, p. 2833-2839
Publication date2015
Abstract

The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.

Keywords
  • Asymmetric bromine–lithium exchange
  • Atropoisomeric ligands
  • Catalytic phosphination
  • Dihedral angles
  • Diphosphines
Research group
Citation (ISO format)
GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced synthesis & catalysis, 2015, vol. 357, n° 13, p. 2833–2839. doi: 10.1002/adsc.201500323
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Article (Published version)
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Identifiers
ISSN of the journal1615-4150
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Technical informations

Creation09/17/2015 4:00:00 PM
First validation09/17/2015 4:00:00 PM
Update time03/14/2023 11:37:32 PM
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