Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Graff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederick; Alexakis, Alexandre

doi:10.1002/adsc.201500323

Scientific article

English

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

ContributorsGraff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederick; Alexakis, Alexandre

Published inAdvanced synthesis & catalysis, vol. 357, no. 13, p. 2833-2839

Publication date2015

Abstract

The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.

Keywords

Asymmetric bromine–lithium exchange
Atropoisomeric ligands
Catalytic phosphination
Dihedral angles
Diphosphines

Affiliation entities

Research groups

Groupe Alexakis

Citation (ISO format)

GRAFF, Julien et al. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. In: Advanced synthesis & catalysis, 2015, vol. 357, n° 13, p. 2833–2839. doi: 10.1002/adsc.201500323

Article (Published version)

Identifiers

PID : unige:75306
DOI : 10.1002/adsc.201500323

Journal ISSN1615-4150

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Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

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