Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Article Article scientifique Article Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands eng 2015 author Graff Julien 732146 author Lastawiecka Elzbieta 794974 author Guenee Laure 115015 author Leroux Frederick author Alexakis Alexandre 123950 2833-2839 10.1002/adsc.201500323 1615-4150 The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields. Asymmetric bromine–lithium exchange Atropoisomeric ligands Catalytic phosphination Dihedral angles Diphosphines Dewey 540 36 Département de chimie organique 141 40 Département de chimie minérale, analytique et appliquée 145 false 759 Groupe Alexakis Advanced synthesis & catalysis 357 13 1e59d424-4911-4ead-987a-a35b8f591cf1 Article (Published version) Restricted Graff_et_al-2015-Advanced_Synthesis_&_Catalysis.pdf 1016442 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique Faculté des sciences / Section de chimie et biochimie / Département de chimie minérale, analytique et appliquée

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands	Advanced synthesis & catalysis			2015	625	2

Archive ouverte UNIGE

Lastawiecka, Elzbieta