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Acute oxidtive stress responses in the microalga Chlamydomonas reinhardtii exposed to metal oxide nanoparticles

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Defense Thèse de doctorat : Univ. Genève, 2015 - Sc. 4804 - 2015/06/29
Abstract This thesis treats the subject of the potential impact of engineered metal oxide nanomaterials (ENMs) on environmental health and covers aspects from the exposure side to the associated biological hazards. The main objective was to shed light on the short-term dynamics of potential sub-toxic, ENM induced pro-oxidant processes, to develop the link between cell-free and cellular prooxidant processes and to unravel modifying factors thereof. Chlamydomonas reinhardtii served as a model organism and was exposed to nano-CuO and nano-TiO2. Major findings include the observation that agglomeration does not preclude ENM induced pro-oxidant effects, that ambient exposure conditions play a decisive role in determining the toxicity-mediating factor (i.e. particles vs. ions vs mobile ROS) and significantly influence the short-term dynamics of cellular oxidative stress responses and finally, the observation that extra- and intracellular pro-oxidant processes can differ significantly, which may give rise to misleading and conflicting conclusions when considered individually.
Keywords NanoecotoxicologyRisk assessmentReactive oxygen speciesPro-oxidant effectsFlow cytometry
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URN: urn:nbn:ch:unige-752740
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Project FNS: NRP 64
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VON MOOS, Nadia Rachel. Acute oxidtive stress responses in the microalga Chlamydomonas reinhardtii exposed to metal oxide nanoparticles. Université de Genève. Thèse, 2015. https://archive-ouverte.unige.ch/unige:75274

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Deposited on : 2015-09-21

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