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Is cytosolic ionized calcium regulating neutrophil activation?

Pozzan, T.
Tsien, R. Y.
Published in Science. 1983, vol. 221, no. 4618, p. 1413-1415
Abstract The concentration of cytosolic ionized calcium, [Ca2+]i, was measured in intact neutrophils by use of a fluorescent indicator trapped in the icytoplasm. A given rise of [Ca2+]i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2+]i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors. Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca2+]i and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca2+]i as is widely supposed.
Keywords Calcium/ physiologyCytoplasm/physiologyEthers/pharmacologyExocytosisHumansIonomycinIonophores/pharmacologyLysosomes/enzymologyN-Formylmethionine/analogs & derivatives/pharmacologyN-Formylmethionine Leucyl-PhenylalanineNeutrophils/ physiologyOligopeptides/pharmacologyOxygen/ metabolismSuperoxides/ metabolism
PMID: 6310757
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POZZAN, T. et al. Is cytosolic ionized calcium regulating neutrophil activation?. In: Science, 1983, vol. 221, n° 4618, p. 1413-1415. doi: 10.1126/science.6310757 https://archive-ouverte.unige.ch/unige:7525

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Deposited on : 2010-06-21

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