Article - Limited access to UNIGE
Is cytosolic ionized calcium regulating neutrophil activation?
|Published in||Science. 1983, vol. 221, no. 4618, p. 1413-1415|
|Abstract||The concentration of cytosolic ionized calcium, [Ca2+]i, was measured in intact neutrophils by use of a fluorescent indicator trapped in the icytoplasm. A given rise of [Ca2+]i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2+]i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors. Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca2+]i and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca2+]i as is widely supposed.|
|Keywords||Calcium/ physiology — Cytoplasm/physiology — Ethers/pharmacology — Exocytosis — Humans — Ionomycin — Ionophores/pharmacology — Lysosomes/enzymology — N-Formylmethionine/analogs & derivatives/pharmacology — N-Formylmethionine Leucyl-Phenylalanine — Neutrophils/ physiology — Oligopeptides/pharmacology — Oxygen/ metabolism — Superoxides/ metabolism|
|POZZAN, T. et al. Is cytosolic ionized calcium regulating neutrophil activation?. In: Science, 1983, vol. 221, n° 4618, p. 1413-1415. doi: 10.1126/science.6310757 https://archive-ouverte.unige.ch/unige:7525|