UNIGE document Scientific Article
previous document  unige:74982  next document
add to browser collection

Role of PAR-4 in ovarian cancer

Ribaux, Pascale
Published in Oncotarget. 2015, vol. 6, no. 26, p. 22641-22652
Abstract Prostate apoptosis response-4 (PAR-4) is considered as a tumour suppressor due to its ability to selectively induce cell apoptosis in most cancer cells. However little is known about the role of PAR-4 in ovarian cancer. In this study, we investigated for the first time the role of PAR-4 in ovarian carcinogenesis. We showed that PAR-4 mRNA level is not significantly different between healthy and cancer ovarian cells. Immunohistochemistry on ovarian tissue showed that ovarian cancer cells are positive for PAR-4 nuclear and cytoplasmic staining whereas ovarian healthy cells are negative for PAR-4 nuclear staining. We then studied the role of PAR-4 in cell apoptosis. We determined that PAR-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of GRP78 from endoplasmic reticulum to the cell surface of ovarian cancer cell line (SKOV-3 cells). In ovo, PAR-4 decreases ovarian tumour development and increases the response to taxol treatment. These observations suggest that PAR-4 is a very interesting therapeutic target against ovarian carcinogenesis.
PMID: 26246468
Full text
Article (Published version) (2.7 MB) - public document Free access
Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
(ISO format)
MEYNIER, Sonia et al. Role of PAR-4 in ovarian cancer. In: Oncotarget, 2015, vol. 6, n° 26, p. 22641-22652. doi: 10.18632/oncotarget.4010 https://archive-ouverte.unige.ch/unige:74982

482 hits



Deposited on : 2015-09-01

Export document
Format :
Citation style :