Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma

Vaillant, Catherine; Valdivieso, Paola; Nuciforo, Sandro; Kool, Marcel; Schwarzentruber-Schauerte, Alexandra; Méreau, Hélène; Cabuy, Erik; Lobrinus, Johannes Alexander; Pfister-chionne, Stefania Anna; Zuniga, Aimée; Frank, Stephan; Zeller, Rolf

doi:10.1371/journal.pone.0124870

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Title		Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma
Authors		Vaillant, Catherine Valdivieso, Paola Nuciforo, Sandro Kool, Marcel Schwarzentruber-Schauerte, Alexandra Méreau, Hélène Cabuy, Erik Lobrinus, Johannes Alexander Pfister-chionne, Stefania Anna Zuniga, Aimée Frank, Stephan Zeller, Rolf show all authors [1 - 12]
Published in		PloS one. 2015, vol. 10, no. 4, e0124870
Abstract		Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1) receptor or downstream effectors. Mice carrying a Patched-1 null allele (Ptch1∆/+) are a good model to study the alterations underlying medulloblastoma development as a consequence of aberrant Hedgehog pathway activity.
Identifiers		DOI: 10.1371/journal.pone.0124870 PMID: 25901736
Full text		Article (Published version) (7.5 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Métastases du foie (657)
Citation (ISO format)		VAILLANT, Catherine et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. In: PloS one, 2015, vol. 10, n° 4, p. e0124870. doi: 10.1371/journal.pone.0124870 https://archive-ouverte.unige.ch/unige:74779