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Title

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma

Authors
Vaillant, Catherine
Valdivieso, Paola
Nuciforo, Sandro
Kool, Marcel
Schwarzentruber-Schauerte, Alexandra
Méreau, Hélène
Cabuy, Erik
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Published in PLOS ONE. 2015, vol. 10, no. 4, p. e0124870
Abstract Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1) receptor or downstream effectors. Mice carrying a Patched-1 null allele (Ptch1∆/+) are a good model to study the alterations underlying medulloblastoma development as a consequence of aberrant Hedgehog pathway activity.
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PMID: 25901736
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Article (Published version) (7.5 MB) - public document Free access
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Research group Métastases du foie (657)
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VAILLANT, Catherine et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. In: PLOS ONE, 2015, vol. 10, n° 4, p. e0124870. https://archive-ouverte.unige.ch/unige:74779

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Deposited on : 2015-08-19

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