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Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma

Published inPloS one, vol. 10, no. 4, e0124870
Publication date2015
Abstract

Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1) receptor or downstream effectors. Mice carrying a Patched-1 null allele (Ptch1∆/+) are a good model to study the alterations underlying medulloblastoma development as a consequence of aberrant Hedgehog pathway activity.

Citation (ISO format)
VAILLANT, Catherine et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. In: PloS one, 2015, vol. 10, n° 4, p. e0124870. doi: 10.1371/journal.pone.0124870
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ISSN of the journal1932-6203
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Creation07/31/2015 12:03:00 PM
First validation07/31/2015 12:03:00 PM
Update time03/14/2023 11:34:24 PM
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