Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma

Article Article scientifique Article Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma eng 2015 author Vaillant Catherine author Valdivieso Paola author Nuciforo Sandro author Kool Marcel author Schwarzentruber-Schauerte Alexandra author Méreau Hélène author Cabuy Erik author Lobrinus Johannes Alexander 647649 author Pfister-chionne Stefania Anna 668809 author Zuniga Aimée author Frank Stephan author Zeller Rolf e0124870 10.1371/journal.pone.0124870 25901736 1932-6203 Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1) receptor or downstream effectors. Mice carrying a Patched-1 null allele (Ptch1∆/+) are a good model to study the alterations underlying medulloblastoma development as a consequence of aberrant Hedgehog pathway activity. Dewey 616.07 137 Département de pathologie et immunologie 21F false 391 Métastases du foie 657 PloS one 10 4 cad20269-8718-40f3-8635-a056e5ec47d7 Article (Published version) Public journal.pone.0124870.pdf 7871313 application/pdf CC BY openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma	PloS one			2015	532	457

Archive ouverte UNIGE

Pfister-chionne, Stefania Anna