UNIGE document Scientific Article
previous document  unige:74763  next document
add to browser collection
Title

Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy

Authors
Mezey, E
Skirboll, L
Published in Proceedings of the National Academy of Sciences. 1984, vol. 81, no. 6, p. 1854-8
Abstract The immunoperoxidase technique was used to study the effect of adrenalectomy on vasopressin (VP) immunoreactivity in the hypothalamic paraventricular nucleus of rat. In control animals, relatively few VP-immunostained parvocellular neurons were found in addition to a large population of magnocellular VP neurons. Seven to 14 days after bilateral adrenalectomy, VP immunostaining increased markedly in specific subdivisions of the paraventricular nucleus. In contrast to normal animals, VP immunoreactivity was localized in a large number of parvocellular neurons. Colchicine treatment, on the other hand, did not significantly increase the number of VP-immunostained parvocellular neurons found in control rats. These observations suggest that adrenalectomy increases the number of VP-positive neurons and appears to increase the intensity of VP immunoreactivity specifically in parvocellular neurons. VP parvocellular neurons are confined to those paraventricular nucleus subdivisions that are known to project to the external zone of the median eminence. Moreover, their distribution pattern is very similar, if not identical, to that of the corticotropin-releasing factor (CRF) immunoreactive cells. Parvocellular neurons on adjacent thin sections could be stained for both CRF and VP. Thus, adrenalectomy seems to increase VP staining in CRF immunoreactive parvocellular neurons, which innervate the external zone of the median eminence.
Keywords AdrenalectomyAnimalsColchicine/pharmacologyCorticotropin-Releasing Hormone/metabolismMaleParaventricular Hypothalamic Nucleus/metabolismRatsVasopressins/metabolism
Identifiers
PMID: 6608732
Full text
Article (Published version) (2.4 MB) - public document Free access
Structures
Research group Progéniteurs neuronaux (141)
Citation
(ISO format)
KISS, Jozsef Zoltan, MEZEY, E, SKIRBOLL, L. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy. In: Proceedings of the National Academy of Sciences, 1984, vol. 81, n° 6, p. 1854-8. https://archive-ouverte.unige.ch/unige:74763

151 hits

36 downloads

Update

Deposited on : 2015-08-19

Export document
Format :
Citation style :