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Title

Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy

Authors
Marchal, F.
Schockmel, G. A.
Fox, C. H.
Pantaleo, G.
Published in Journal of Infectious Diseases. 1998, vol. 177, no. 6, p. 1497-1501
Abstract At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 (HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in blood and lymphoid tissues 9-18 months after initiation of treatment. These markers include plasma viremia, measured with a sensitive assay with a detection limit of 20 HIV-1 RNA copies/mL, infectious virus titers and proviral DNA in lymph node mononuclear cells, and HIV-1 RNA in lymphoid tissue. Five subjects had plasma viremia <20 copies/mL and showed no evidence of viral replication in lymphoid tissue. Six subjects had both detectable plasma viremia and evidence of HIV-1 RNA in lymphoid tissue. The results indicate that absence of detectable HIV RNA in lymphoid tissue is associated with viremia levels of HIV-1 RNA <20 copies/mL.
Keywords Adenoids/pathology/virologyAdultAnti-HIV Agents/ therapeutic useCD4-CD8 RatioDNA, Viral/analysisDendritic Cells/virologyDidanosine/ therapeutic useDrug Therapy, CombinationFemaleHIV Infections/ drug therapy/pathology/ virologyHIV-1/genetics/ physiologyHumansLymph Nodes/pathology/ virologyMaleMiddle AgedPalatine Tonsil/pathology/virologyProviruses/geneticsReverse Transcriptase Inhibitors/ therapeutic useViral LoadVirus ReplicationZidovudine/ therapeutic use
Identifiers
PMID: 9607825
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Other version: http://www.journals.uchicago.edu/doi/pdf/10.1086/515303
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PERRIN, Luc et al. Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy. In: Journal of Infectious Diseases, 1998, vol. 177, n° 6, p. 1497-1501. https://archive-ouverte.unige.ch/unige:7469

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Deposited on : 2010-06-21

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