Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy

Oxenius, Annette; McLean, A. R.; Fischer, Marek; Price, D. A.; Dawson, S. J.; Hafner, Roland; Schneider, Christine; Joller, Helen; Hirschel, Bernard; Phillips, R. E.; Weber, Rainer; Gunthard, Huldrych

doi:10.1128/jvi.76.20.10169-10176.2002

Scientific article

English

Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy

Contributors

Oxenius, Annette; McLean, A. R.; Fischer, Marek; Price, D. A.; Dawson, S. J.; Hafner, Roland; Schneider, Christine; Joller, Helen; Hirschel, Bernard; Phillips, R. E.; Weber, Rainer; Gunthard, Huldrych

Published in

Journal of virology, vol. 76, no. 20, p. 10169-10176

Publication date

2002

Abstract

There is a continuing search for better ways to use existing drugs against human immunodeficiency virus (HIV). One idea is to use short therapy interruptions to "autovaccinate" HIV-infected patients. A group of 13 chronically HIV-infected patients enrolled in a trial of such so-called structured treatment interruptions (STIs) were intensively studied with respect to their viral load (VL) and HIV-specific CD8+ T-cell (cytotoxic T-lymphocyte [CTL]) responses. We found that 10 of the 13 patients had plateau VLs after STIs that were lower than their pretreatment VLs. While viral rebound rates became lower over STIs, there were no changes in clearance rates. Although numbers of CTLs did increase over the same time that viral rebounds decreased, there was no correlation between CTL count and either viral rebound rates or clearance rates. Finally, we asked whether absolute numbers of or changes in numbers of CTLs predict plateau VLs after STIs. No measure of CTLs was able to predict plateau VLs. Thus, there was no signature in these data of an important contribution to virological control from HIV-specific CD8+ T lymphocytes.

Keywords

Adult
Aged
CD8-Positive T-Lymphocytes/immunology
HIV Infections/drug therapy/ immunology/virology
HIV-1/genetics/growth & development/ immunology
Humans
Middle Aged
RNA, Viral/blood
T-Lymphocytes, Cytotoxic/ immunology
Viral Load

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

OXENIUS, Annette et al. Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. In: Journal of virology, 2002, vol. 76, n° 20, p. 10169–10176. doi: 10.1128/jvi.76.20.10169-10176.2002

Article

Identifiers

PID : unige:7456
DOI : 10.1128/jvi.76.20.10169-10176.2002
PMID : 12239291

Additional URL for this publication

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136545/pdf/0463.pdf

Journal ISSN

0022-538X

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21/06/2010 10:25:35

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21/06/2010 10:25:35

Update

14/03/2023 15:44:54

Status update

14/03/2023 15:44:53

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29/10/2024 15:15:55

Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

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Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation