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Master
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HoxD gene regulation in the developing mammary bud

ContributorsSchep, Ruben
Master program titleMaster en biologie, option génétique, dévelopment et évolution
Defense date2015
Abstract

Hox genes are key transcription factors for the establishment of the rostro-caudal axis in Bilaterian development. Over the course of evolution, they acquired several new functions within vertebrate- and mammalian-specific structures. Among these, Hox genes seem to be required for the correct development and function of embryonic and adult mammary glands. Members of the Hox9 paralogy group are indeed expressed in the developing mammary mesenchyme and the loss of function of Hoxd9 in lactating females caused 50% lethality of the offspring by milk starvation due to hypoplasia of the mammary glands (Chen and Capecchi, 1999). In this study, we characterized the transcription profiles of embryonic mammary glands to globally describe their Hoxome. Interestingly, Hoxd9 is the only Hoxd gene significantly expressed in the mammary bud. We identified a 20kb large region located approximately 300kb downstream the HoxD cluster and containing seven evolutionary conserved sequences. This DNA segment is essential to drive expression of Hoxd9 in the mammary bud.

eng
Keywords
  • Hox
  • Hoxd
  • Hoxd9
  • Mammals
  • Mammary bud
  • Development
  • Gene regulation
  • Enhancer
Research group
Citation (ISO format)
SCHEP, Ruben. HoxD gene regulation in the developing mammary bud. 2015.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:74551
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Technical informations

Creation08/04/2015 3:14:00 PM
First validation08/04/2015 3:14:00 PM
Update time03/14/2023 11:31:59 PM
Status update03/14/2023 11:31:59 PM
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