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Scientific article
English

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

Publication date2013
Abstract

To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral suppression.

Keywords
  • Adult
  • Anti-Retroviral Agents/administration & dosage/pharmacokinetics
  • Antiretroviral Therapy, Highly Active/methods
  • Benzoxazines/administration & dosage/pharmacokinetics
  • Cerebrospinal Fluid/chemistry/virology
  • Female
  • HIV Infections/drug therapy/virology
  • HIV-1/isolation & purification
  • Humans
  • Lopinavir/administration & dosage/pharmacokinetics
  • Male
  • Middle Aged
  • Oligopeptides/administration & dosage/pharmacokinetics
  • Plasma/chemistry/virology
  • Pyridines/administration & dosage/pharmacokinetics
  • RNA, Viral/cerebrospinal fluid
  • Treatment Outcome
  • Viral Load
Citation (ISO format)
CUSINI, Alexia et al. Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid. In: Journal of acquired immune deficiency syndromes and human retrovirology, 2013, vol. 62, n° 1, p. 28–35. doi: 10.1097/QAI.0b013e318274e2b0
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1077-9450
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Creation07/20/2015 2:46:00 PM
First validation07/20/2015 2:46:00 PM
Update time03/14/2023 11:31:36 PM
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