Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

Cusini, Alexia; Vernazza, Pietro L; Yerly Ferrillo, Sabine; Decosterd, Laurent A; Ledergerber, Bruno; Fux, Christoph A; Rohrbach, Janine; Widmer, Nicolas; Hirschel, Bernard; Gaudenz, Roman; Cavassini, Matthias; Klimkait, Thomas; Zenger, Franziska; Gutmann, Chistine; Opravil, Milos; Günthard, Huldyrich F

doi:10.1097/QAI.0b013e318274e2b0

Scientific article

English

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

ContributorsCusini, Alexia; Vernazza, Pietro L; Yerly Ferrillo, Sabine; Decosterd, Laurent A; Ledergerber, Bruno; Fux, Christoph A; Rohrbach, Janine; Widmer, Nicolas

; Hirschel, Bernard; Gaudenz, Roman; Cavassini, Matthias; Klimkait, Thomas; Zenger, Franziska; Gutmann, Chistine; Opravil, Milos; Günthard, Huldyrich F

Published inJournal of acquired immune deficiency syndromes and human retrovirology, vol. 62, no. 1, p. 28-35

Publication date2013

Abstract

To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral suppression.

Keywords

Adult
Anti-Retroviral Agents/administration & dosage/pharmacokinetics
Antiretroviral Therapy, Highly Active/methods
Benzoxazines/administration & dosage/pharmacokinetics
Cerebrospinal Fluid/chemistry/virology
Female
HIV Infections/drug therapy/virology
HIV-1/isolation & purification
Humans
Lopinavir/administration & dosage/pharmacokinetics
Male
Middle Aged
Oligopeptides/administration & dosage/pharmacokinetics
Plasma/chemistry/virology
Pyridines/administration & dosage/pharmacokinetics
RNA, Viral/cerebrospinal fluid
Treatment Outcome
Viral Load

Affiliation entities

Research groups

Groupe Laurent Kaiser (virologie clinique) (668)

Citation (ISO format)

CUSINI, Alexia et al. Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid. In: Journal of acquired immune deficiency syndromes and human retrovirology, 2013, vol. 62, n° 1, p. 28–35. doi: 10.1097/QAI.0b013e318274e2b0

Article (Published version)

Identifiers

PID : unige:74514
DOI : 10.1097/QAI.0b013e318274e2b0
PMID : 23018371

Journal ISSN1077-9450

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First validation20/07/2015 14:46:00

Update time14/03/2023 23:31:36

Status update14/03/2023 23:31:35

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Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral suppression.

Technical informations