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Title

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

Authors
Cusini, Alexia
Vernazza, Pietro L
Decosterd, Laurent A
Ledergerber, Bruno
Fux, Christoph A
Rohrbach, Janine
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Published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 2013, vol. 62, no. 1, p. 28-35
Abstract To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral suppression.
Keywords AdultAnti-Retroviral Agents/administration & dosage/pharmacokineticsAntiretroviral Therapy, Highly Active/methodsBenzoxazines/administration & dosage/pharmacokineticsCerebrospinal Fluid/chemistry/virologyFemaleHIV Infections/drug therapy/virologyHIV-1/isolation & purificationHumansLopinavir/administration & dosage/pharmacokineticsMaleMiddle AgedOligopeptides/administration & dosage/pharmacokineticsPlasma/chemistry/virologyPyridines/administration & dosage/pharmacokineticsRNA, Viral/cerebrospinal fluidTreatment OutcomeViral Load
Identifiers
PMID: 23018371
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Article (Published version) (168 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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CUSINI, Alexia et al. Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 2013, vol. 62, n° 1, p. 28-35. https://archive-ouverte.unige.ch/unige:74514

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Deposited on : 2015-08-06

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