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A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection |
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Published in | The Journal of Infectious Diseases. 2002, vol. 185, no. 9, p. 1251-1260 | |
Abstract | This randomized study evaluated the efficacy and tolerability of continued treatment with protease inhibitor plus nucleoside-analogue combination regimens (n=79) or a change to the simplified regimen of abacavir-lamivudine-zidovudine (n=84) in patients with suppressed human immunodeficiency virus type 1 (HIV-1) RNA for > or = 6 months who did not have the reverse transcriptase 215 mutation. After a median follow-up of 84 weeks, virologic failure was 6% in the continuation and 15% in the simplified group (P=.081). Previous zidovudine monotherapy or dual therapy and archived reverse transcriptase resistance mutations in HIV-1 DNA at baseline were significant predictors of failure. Study treatment was discontinued because of adverse events in 20% of the continuation and 7% of the simplified group (P=.021). Simplification to abacavir-lamivudine-zidovudine significantly decreased nonfasting cholesterol and triglyceride levels; however, this switch strategy carries a risk of virologic failure when treatment history or resistance testing suggest the presence of archived resistance mutations to the simplified regimen. | |
Keywords | Acquired Immunodeficiency Syndrome/ drug therapy/metabolism/virology — Anti-HIV Agents/ administration & dosage — Dideoxynucleosides/ administration & dosage — Drug Therapy, Combination — Female — Hiv-1 — Humans — Lamivudine/ administration & dosage — Lipids/blood — Male — Prospective Studies — RNA, Viral/blood — Treatment Failure — Viral Load — Zidovudine/ administration & dosage | |
Identifiers | DOI: 10.1086/340312 PMID: 12001042 | |
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Citation (ISO format) | OPRAVIL, Milos et al. A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection. In: The Journal of Infectious Diseases, 2002, vol. 185, n° 9, p. 1251-1260. doi: 10.1086/340312 https://archive-ouverte.unige.ch/unige:7451 |