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Viral escape in the CNS with multidrug-resistant HIV-1

Bertschi, Manuel
de Jong, Denise
Rauch, Andri
Cusini, Alexia
Published in Journal of the International AIDS Society. 2014, vol. 17, no. 4 Suppl 3, 19745
Abstract HIV-1 viral escape in the cerebrospinal fluid (CSF) despite viral suppression in plasma is rare [1,2]. We describe the case of a 50-year-old HIV-1 infected patient who was diagnosed with HIV-1 in 1995. Antiretroviral therapy (ART) was started in 1998 with a CD4 T cell count of 71 cells/ìL and HIV-viremia of 46,000 copies/mL. ART with zidovudine (AZT), lamivudine (3TC) and efavirenz achieved full viral suppression. After the patient had interrupted ART for two years, treatment was re-introduced with tenofovir (TDF), emtricitabin (FTC) and ritonavir boosted atazanavir (ATVr). This regimen suppressed HIV-1 in plasma for nine years and CD4 cells stabilized around 600 cells/ìL. Since July 2013, the patient complained about severe gait ataxia and decreased concentration.
PMID: 25397490
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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BEGUELIN, Charles et al. Viral escape in the CNS with multidrug-resistant HIV-1. In: Journal of the International AIDS Society, 2014, vol. 17, n° 4 Suppl 3, p. 19745. doi: 10.7448/IAS.17.4.19745 https://archive-ouverte.unige.ch/unige:74508

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Deposited on : 2015-08-06

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