Viral escape in the CNS with multidrug-resistant HIV-1

Article Article scientifique Article Viral escape in the CNS with multidrug-resistant HIV-1 eng 2014 author Beguelin Charles 768398 author Vazquez Rodriguez Miriam 504549 author Bertschi Manuel author Yerly Ferrillo Sabine 23752 author de Jong Denise author Rauch Andri author Cusini Alexia 19745 10.7448/IAS.17.4.19745 25397490 1758-2652 HIV-1 viral escape in the cerebrospinal fluid (CSF) despite viral suppression in plasma is rare [1,2]. We describe the case of a 50-year-old HIV-1 infected patient who was diagnosed with HIV-1 in 1995. Antiretroviral therapy (ART) was started in 1998 with a CD4 T cell count of 71 cells/ìL and HIV-viremia of 46,000 copies/mL. ART with zidovudine (AZT), lamivudine (3TC) and efavirenz achieved full viral suppression. After the patient had interrupted ART for two years, treatment was re-introduced with tenofovir (TDF), emtricitabin (FTC) and ritonavir boosted atazanavir (ATVr). This regimen suppressed HIV-1 in plasma for nine years and CD4 cells stabilized around 600 cells/ìL. Since July 2013, the patient complained about severe gait ataxia and decreased concentration. Dewey 616 56 Département de médecine 221 false 400 Virologie clinique 668 Journal of the International AIDS Society 17 4 Suppl 3 3edee7bc-9520-4ae8-85b8-e4770b93985e Article (Published version) Public Viral escape in the CNS with multidrug-resitant HIV-1.pdf 76226 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Viral escape in the CNS with multidrug-resistant HIV-1	Journal of the International AIDS Society			2014	717	286

Archive ouverte UNIGE

Vazquez Rodriguez, Miriam