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Title

Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection

Authors
Nuesch, Reto
Ananworanich, Jintanat
Srasuebkul, Preeyaporn
Chetchotisakd, Ploenchan
Prasithsirikul, Wisit
Klinbuayam, Wirat
Mahanontharit, Apicha
Jupimai, Thidarat
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Published in AIDS. 2008, vol. 22, no. 1, p. 152-154
Abstract Thai patients enrolled in STACCATO with HIV/hepatitis B virus (HBV) co-infection and tenofovir/emtricitabine-based antiretroviral therapy (ART) were randomly assigned to continuous treatment or CD4 cell count-guided interruptions. HBV replication was suppressed below detection in 15/16 patients. Structured treatment interruption increased transaminases and HBV viraemia in five of six patients; one flare was severe. Conversion to anti-hepatitis Be occurred with continuous treatment only. Tenofovir/emtricitabine-containing ART is highly effective in controlling chronic HIV/HBV co-infection but treatment should not be interrupted.
Keywords Adenine/administration & dosage/ analogs & derivativesAnti-Retroviral Agents/administration & dosageAntiretroviral Therapy, Highly ActiveAntiviral Agents/ administration & dosageDeoxycytidine/administration & dosage/ analogs & derivativesDrug Administration ScheduleFemaleHivHIV Infections/ complications/ drug therapyHepatitis B e Antigens/bloodHepatitis B virus/immunology/isolation & purificationHepatitis B, Chronic/blood/ complications/ drug therapy/virologyHumansMalePhosphonic Acids/ administration & dosageThailandTransaminases/bloodTreatment OutcomeViral Load
Identifiers
PMID: 18090405
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NUESCH, Reto et al. Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection. In: AIDS, 2008, vol. 22, n° 1, p. 152-154. https://archive-ouverte.unige.ch/unige:7447

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Deposited on : 2010-06-21

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