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Title

Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin
Authors
Kanaka-Gantenbein, C
Catzeflis, Chantal
Keller, U
Fathi, Marc
Theintz, Gérald Edouard
Sizonenko, Pierre-Claude
Published in Journal of Pediatric Endocrinology and Metabolism. 1999, vol. 12, no. 1, p. 39-46
Abstract After transfer of diabetic patients from porcine to human insulin, many reports emerged supporting an increased hypoglycemia unawareness. Several studies were then undertaken in both diabetic and healthy adults to investigate counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia as a possible underlying cause for this different hypoglycemia awareness. Most studies demonstrated similar neuroendocrine responses to both insulin species in adults. However, no such studies have ever been performed in healthy children. We undertook a double-blinded study of counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia in 17 short normal children randomly assigned to two groups, one receiving human and the other porcine insulin. We found similar responses of growth hormone, cortisol, epinephrine, norepinephrine and dopamine to both porcine insulin- and human insulin- induced hypoglycemia. Interestingly, we observed a significantly higher glucagon secretion when hypoglycemia was induced by human insulin. In conclusion, human insulin induces a higher glucagon secretion in healthy children than porcine insulin. Evidently, this observation cannot be extrapolated to diabetic patients. This study, however, further underlines the importance of performing investigations in children, since results found in adults differ from those observed in children.
Keywords Adolescent — Animals — Blood Glucose/metabolism — Catecholamines/blood — Child — Double-Blind Method — Female — Glucagon/blood/metabolism — Growth Disorders/blood — Growth Hormone/blood — Humans — Hydrocortisone/blood — Hypoglycemia/blood/chemically induced — Insulin/pharmacology — Male — Species Specificity — Swine
Identifiers
PMID: 10392347
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Citation
(ISO format) 		KANAKA-GANTENBEIN, C et al. Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin. In: Journal of Pediatric Endocrinology and Metabolism, 1999, vol. 12, n° 1, p. 39-46. doi: 10.1515/jpem.1999.12.1.39 https://archive-ouverte.unige.ch/unige:74347

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Deposited on : 2015-07-27

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