Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin

Article Article scientifique Article Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin eng 1999 author Kanaka-Gantenbein C author Catzeflis Chantal 96453 author Keller U author Fathi Marc 565078 author Theintz Gérald Edouard 26564 author Sizonenko Pierre-Claude 25042 39-46 10.1515/jpem.1999.12.1.39 10392347 0334-018X After transfer of diabetic patients from porcine to human insulin, many reports emerged supporting an increased hypoglycemia unawareness. Several studies were then undertaken in both diabetic and healthy adults to investigate counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia as a possible underlying cause for this different hypoglycemia awareness. Most studies demonstrated similar neuroendocrine responses to both insulin species in adults. However, no such studies have ever been performed in healthy children. We undertook a double-blinded study of counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia in 17 short normal children randomly assigned to two groups, one receiving human and the other porcine insulin. We found similar responses of growth hormone, cortisol, epinephrine, norepinephrine and dopamine to both porcine insulin- and human insulin- induced hypoglycemia. Interestingly, we observed a significantly higher glucagon secretion when hypoglycemia was induced by human insulin. In conclusion, human insulin induces a higher glucagon secretion in healthy children than porcine insulin. Evidently, this observation cannot be extrapolated to diabetic patients. This study, however, further underlines the importance of performing investigations in children, since results found in adults differ from those observed in children. Adolescent Animals Blood Glucose/metabolism Catecholamines/blood Child Double-Blind Method Female Glucagon/blood/metabolism Growth Disorders/blood Growth Hormone/blood Humans Hydrocortisone/blood Hypoglycemia/blood/chemically induced Insulin/pharmacology Male Species Specificity Swine Dewey 615 Dewey 618 31 Section des sciences pharmaceutiques 17 58 Département de pédiatrie, gynécologie et obstétrique 223 false Journal of pediatric endocrinology & metabolism 12 1 4a2bd5aa-b677-4567-80ff-1a7f92edbf9e Article (Published version) Restricted 39-46.pdf 1184558 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin	Journal of pediatric endocrinology & metabolism			1999	582	0

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Catzeflis, Chantal