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Scientific article
Review
French

Génomique et métagénomique bactériennes : applications cliniques et importance médicale

Contributors

Diene, S M; Bertelli, C; Pillonel, Trestan; Schrenzel, Jacques; Greub, Gilbert Daniel

Published in

Revue médicale suisse, vol. 10, no. 450, p. 2155-2161

Publication date

2014

Abstract

New sequencing technologies provide in a short time and at low cost high amount of genomic sequences useful for applications such as: a) development of diagnostic PCRs and/or serological tests; b) detection of virulence factors (virulome) or genes/SNPs associated with resistance to antibiotics (resistome) and c) investigation of transmission and dissemination of bacterial pathogens. Thus, bacterial genomics of medical importance is useful to clinical microbiologists, to infectious diseases specialists as well as to epidemiologists. Determining the microbial composition of a sample by metagenomics is another application of new sequencing technologies, useful to understand the impact of bacteria on various non-infectious diseases such as obesity, asthma, or diabetes. Genomics and metagenomics will likely become a specialized diagnostic analysis.

Keywords

  • Anti-Bacterial Agents/pharmacology
  • Bacteria/genetics/isolation & purification
  • Bacterial Infections/diagnosis/microbiology
  • Drug Resistance, Bacterial
  • Genome, Bacterial
  • Genomics/methods
  • Humans
  • Metagenomics/methods

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

DIENE, S M et al. Génomique et métagénomique bactériennes : applications cliniques et importance médicale. In: Revue médicale suisse, 2014, vol. 10, n° 450, p. 2155–2161.

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://www.revmed.ch/rms/2014/RMS-N-450/Genomique-et-metagenomique-bacteriennes-applications-cliniques-et-importance-medicale

Journal ISSN

1660-9379
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Technical informations

Creation

16/06/2015 12:27:00

First validation

16/06/2015 12:27:00

Update

13/01/2025 13:44:30

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