δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity
Published inThe Journal of biological chemistry, vol. 289, no. 51, p. 35341-35350
Publication date2014
Abstract
Keywords
- Acids/chemistry
- Amino Acid Sequence
- Animals
- Chromatography, High Pressure Liquid
- Conotoxins/chemical synthesis/chemistry/pharmacology
- Conus Snail/chemistry
- Disulfides/chemistry
- Dose-Response Relationship, Drug
- Female
- Ion Channel Gating/drug effects/genetics/physiology
- Molecular Sequence Data
- Oocytes/drug effects/metabolism/physiology
- Peptide Fragments/chemical synthesis/chemistry/pharmacology
- Protein Isoforms/genetics/physiology
- Solubility
- Spectrometry, Mass, Electrospray Ionization
- Structure-Activity Relationship
- Voltage-Gated Sodium Channels/genetics/physiology
- Xenopus laevis
Research group
Citation (ISO format)
PEIGNEUR, Steve et al. δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity. In: The Journal of biological chemistry, 2014, vol. 289, n° 51, p. 35341–35350. doi: 10.1074/jbc.M114.610436
Main files (1)
Article (Published version)

Identifiers
- PID : unige:73894
- DOI : 10.1074/jbc.M114.610436
- PMID : 25352593
ISSN of the journal0021-9258