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A randomized, controlled trial of indinavir, zidovudine, and lamivudine in adults with advanced human immunodeficiency virus type 1 infection and prior antiretroviral therapy

Authors
Hirsch, M.
Steigbigel, R.
Staszewski, S.
Mellors, J.
Scerpella, E.
Lange, Joep
Squires, K.
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Published in The Journal of Infectious Diseases. 1999, vol. 180, no. 3, p. 659-665
Abstract A randomized, double-blind, multicenter study of indinavir, zidovudine, and lamivudine was conducted in 320 adults with human immunodeficiency virus type 1 (HIV-1) infection, </=50 CD4 cells/mm3, and extensive prior zidovudine therapy. Patients received indinavir, 800 mg every 8 h; zidovudine, 200 mg every 8 h, and lamivudine, 150 mg twice daily; or all 3 drugs for 24 weeks. In an intention-to-treat analysis, proportions of patients with HIV-1 RNA <500 and <50 copies/mL, respectively, at week 24 were 56% and 45% in the indinavir-zidovudine-lamivudine group, 3% and 2% in the indinavir group, and 0% in the zidovudine-lamivudine group. Observed mean CD4 cell increases were 95, 78, and 6 cells/mm3 in the three-, one-, and two-drug arms, respectively. Regimens were generally well tolerated. Patients with advanced HIV-1 infection benefit from triple therapy with indinavir, zidovudine, and lamivudine, although the proportion with optimal response appeared to be lower in patients with low CD4 cell counts.
Keywords Acquired Immunodeficiency Syndrome/ drug therapy/immunology/mortalityAdultAnti-HIV Agents/ therapeutic useCD4 Lymphocyte CountDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleHIV Infections/ drug therapy/immunology/mortalityHiv-1HumansIndinavir/ therapeutic useLamivudine/ therapeutic useMaleSurvival RateZidovudine/ therapeutic use
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PMID: 10438352
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HIRSCH, M. et al. A randomized, controlled trial of indinavir, zidovudine, and lamivudine in adults with advanced human immunodeficiency virus type 1 infection and prior antiretroviral therapy. In: The Journal of Infectious Diseases, 1999, vol. 180, n° 3, p. 659-665. https://archive-ouverte.unige.ch/unige:7316

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Deposited on : 2010-06-21

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