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Wilms' tumor in the adult--report of a case and review of the literature

Tawil, A
Cox, J N
Briner, J
Droz, J P
Published in Pathology - Research and Practice. 1999, vol. 195, no. 2, p. 105-11;discussion113-4
Abstract Wilms' tumor is rare in adults. Its histology, grading and staging are identical to those in children. Investigators agree on a combined modality approach in the treatment of adult Wilms' tumor (AWT), but differ on how aggressive it should be. Some advocate adopting the current pediatric protocols which take into account tumor stage and grade. Others recommend using advanced disease regimens for all stages and grades. We report on an 18 year-old male with stage IV favorable histology Wilms' tumor. The patient underwent radical nephrectomy and received postoperative radiotherapy with intensive four-drug chemotherapy. He had one relapse after 12 months which was successfully treated with chemotherapy and radiotherapy. He remains in remission without relapses 36 months after the initial diagnosis. The genetics of Wilms' tumor has been well studied in children but is practically unknown in adults; karyotype and molecular genetic studies in this case were normal.
Keywords AdolescentAntineoplastic Combined Chemotherapy Protocols/therapeutic useCombined Modality TherapyGenes, Wilms Tumor/geneticsHumansImmunoenzyme TechniquesKaryotypingKidney Neoplasms/chemistry/genetics/pathology/therapyLung Neoplasms/secondary/therapyMaleNeoplasm StagingNephrectomyTomography, X-Ray ComputedTumor Markers, Biological/analysisWilms Tumor/chemistry/genetics/secondary/therapy
PMID: 10093830
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Research group Groupe Roth Arnaud (oncologie) (285)
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TAWIL, A et al. Wilms' tumor in the adult--report of a case and review of the literature. In: Pathology - Research and Practice, 1999, vol. 195, n° 2, p. 105-11;discussion113-4. doi: 10.1016/S0344-0338(99)80081-8 https://archive-ouverte.unige.ch/unige:73156

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Deposited on : 2015-06-10

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